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Professor Andrew McLachlan

Professor of Pharmacy (Aged Care)
Chair of Pharmacy (Aged Care) based at Concord Hospital

Qualifications

BPharm PhD, FPS FACPP MCPA MSHPA

Contact Details

University of Sydney
Message: Eleanor Luntao, Administrative Assistant to Professorial Staff
Phone: +61 2 9351 2360
Concord Office Phone: +61 2 9767 7373
Email:
Fax: +61 2 9351 6950
Pharmacy Building A15, The University of Sydney, NSW 2006 Australia

Concord Hospital
Centre for Education and Research on Ageing
Concord RG Hospital, Building 76, Concord NSW 2139, Australia
Telephone: +61 2 9767 7373
Email:
Web: www.cera.usyd.edu.au

Teaching

Undergraduate and postgraduate teaching in pharmacy practice including Clinical Residency 2 and experiential placements in the hospital setting.

Research Interests

Translating research in clinical pharmacology into practice in the elderly.

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Research Aims

Understanding the causes and consequences of variability in response to medicines and how this informs their quality use. The focus of this research has been in special patient populations such as the elderly, very young and critically ill.

This includes specific projects on the:

  • Impact of ageing on drug disposition and response
  • Optimising pain management in older people
  • Ethnic differences in drug response
  • Herb-drug interactions
  • Genetic basis of response to medicines
  • Optimising anticancer therapies by understanding PK and PD
    variability
  • Therapeutic drug monitoring as a tool to optimized drug therapy
    Optimal anticoagulant monitoring strategies
  • Quality use of medicines
  • Quality and safety in medication management
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Higher Degree Research Candidates

  • El Samman, Fadwa
    Master of Philosophy
    "Medicine and disease information need of older Arabic-speaking Australians"
    Start: February 2007
    Submit: July 2009
    Primary Supervisor: Aslani
  • Giam Lee, Jennifer A.
    Doctor of Philosophy, part-time
    "Quality use of extemporaneous preparations to satisfy unmet medication needs in the community"
    Start: February 2005
    Submit: February 2013
    Primary Supervisor: Krass
  • Liao-Loon, Hannah E.
    Master of Philosophy, part-time
    "Evaluation of medication aspects of integrated home remote monitoring with established respiratory ambulatory care services for Chronic Obstructive Pulmonary Disease (COPD) within the Sydney West Area Health Service (SWAHS)"
    Start: February 2009
    Submit: February 2013
    Primary Supervisor: Armour
  • Nishtala, Shiva P.
    Doctor of Philosophy
    "Psychotropic medicines in older people: Impact of medication reviews"
    Start: February 2007
    Submit: February 2011
    Primary Supervisor: Chen
  • Perera, Vidya
    Doctor of Philosophy
    "Investigation of inter-ethnic differences in CYP1A2 activity."
    Start: February 2008
    Submit: February 2012
    Secondary Supervisor: Gross
  • Sekhon, Bhagwant K.
    Doctor of Philosophy, part-time
    "TBC"
    Start: February 2008
    Submit: February 2012
    Secondary Supervisor: Sze
  • Stocker, Sophie
    Doctor of Philosophy
    "Quality use of urate lowering medicines"
    Start: February 2006
    Submit: February 2010
    Secondary Supervisor: Williams
  • Zeng, Lihua
    Doctor of Philosophy, part-time
    "Clinical pharmacokinetics of mycophenolic acid and acyclovir in children and young people"
    Start: February 2005
    Submit: February 2012
    Secondary Supervisor: Nath
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Previous HDR candidates

  • Dr John Ray -Therapeutic drug monitoring of antiretroviral agents in people with HIV infection
  • Dr Kasia Loboz - Ethnic differences and drug interactions involving the drug metabolising enzyme CYP2B6
  • Mohi Iqbal Mohammed Abdul - Warfarin-Herb Drug interactions
  • Hongmei Xu - Pharmacogenomics of drug interactions with hypoglycaemic drugs
  • Sussan Ghassabian – Understanding variability in clozapine pharmacokinetics in people with schizophrenia
  • Dr Elaine Blair - Population Pharmacokinetics of Anti-cancer drugs
  • Dr Ying Hong - Pharmacokinetics of liposomal amphotericin B in children with cancer
  • Dr Xuemin Xiang - Warfarin-Herb Drug interactions
  • Dr Hamim Zahir - Resolving pharmacokinetic issues to optimise tacrolimus use in liver transplant recipients
  • Dr Lucy Sasongko - Microdialysis in Pharmacokinetics and Pharmacodynamics
  • Dr Mahboubeh Hosseni Yeganeh - Distribution of terbinafine in tissues
  • Dr Christa Nath - Amphotericin B dose optimization in children with malignant disease
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International and National Research Leadership

Editorial Board Membership

  • British Journal of Clinical Pharmacology (Executive Editor, 2008 -)
    Journal of Pharmacy Practice and Research (Associate Editor, 2007 - )
    Journal of Pharmacokinetics and Pharmacodynamics (2006-2009)
    Journal of Pharmacy and Pharmacology (2004-2008)
    Drug Information Journal (2003-2008)
    Australian Medicines Handbook (2001 - )
    Australian Medicines Handbook, Aged Care Companion
    Australian Pharmaceutical Formulary and Handbook

University Service

  • Chair, Postgraduate Coursework Subcommittee and Deputy Chair, Combined Board of Postgraduate Studies in Dentistry, Medicine and Pharmacy (2000-2008)
    Director (Clinical Studies), Herbal Medicines Research and Education Centre, University of Sydney (2003 - )
    Previously Associate Dean (Postgraduate) and Chair, Postgraduate Committee, Faculty of Pharmacy (2000-2005)

Hospital Service

  • Chair, Scientific Subcommittee of the Human Research Ethics Committee SSWAHS (2008 - )
    Member, Human Research Ethics Committee SSWAHS (2008 - )

Professional & Community Contributions

  • Pharmaceutical Health & Rational Use of Medicines (PHARM) Committee (2003 - 2007)
    NSW Poisons Advisory Committee (2003 - 2007)
    Pharmaceutical Subcommittee of the Australian Drug Evaluation Committee (2002 - ongoing)
    Board Member, Australian Sports Anti-Doping Authority (appointed to ASDA in 1999 - )
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Recent Peer Review Publications

2008

  1. Jiang X, Galettis P, Links M, Mitchell PL, McLachlan AJ. Population pharmacokinetics of gemcitabine and its metabolite in patients with cancer: effect of oxaliplatin and infusion rate. Brit J Clin Pharmacol 2008;65:326-33
  2. Stocker SL, Williams KM, McLachlan AJ, Graham GG, Day RO. Pharmacokinetic and Pharmacodynamic Interaction between Allopurinol and Probenecid in Healthy Subjects. Clin Pharmacokinet. 2008;47(2):111-8.
  3. Giam J, Mclachlan AJ. Extemporaneous product use in paediatric patients: a systematic review. International Journal of Pharmacy Practice 2008; 16: 1-8
  4. Xu H, Williams KM, Liauw WS, Murray M, Day RO, McLachlan AJ. Effects of St John's wort and CYP2C9 genotype on the pharmacokinetics and pharmacodynamics of gliclazide. Brit J Pharmacol (in press, accepted 7 Dec 2007)
  5. Zeng L, Nath CE, Shaw PJ, Earl JW, McLachlan AJ. HPLC-fluoresence assay for acyclovir in children. Biomedical Chromatography (in press, accepted 17 Dec, 2007)
  6. Iyer S, Naganathan V, McLachlan A, Le Couteur DG. Medication withdrawal trials in people older than 65 years: a systematic review. Drugs Aging (accepted 11 Feb 2008).
  7. Nishtala P, Bell JS, McLachlan AJ, Chen TF. Psychotropic Prescribing in Long-Term Care Facilities: Impact of Medication Reviews and Educational Interventions. American Journal of Geriatric Psychiatry 2008;16: 621-632.
  8. Zeng L, Nath CE, Shaw PJ, Earl JW, McLachlan AJ. HPLC-UV assay for monitoring total and unbound mycophenolic acid concentrations in children. Biomedical Chromatography 2008 (accepted 17th April 2008)
  9. Mohammed Abdul MI, Jiang X, Williams KM, Day RO, Roufogalis BD, Liauw WS, Xu H, McLachlan AJ. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Brit J Pharmacol (in press, accepted 15th April 2008)
  10. Roos JF, Kirkpatrick CM, Tett SE, McLachlan AJ, Duffull SB. Development of a sufficient design for estimation of fluconazole pharmacokinetics in people with HIV infection. Br J Clin Pharmacol. 2008 Jun 28.

2007

  1. Xu H, Loboz KK, Gross AS, McLachlan AJ. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality 2007;19:163-170.
  2. Hong Y, Shaw PJ, Tattam BN, Nath CE, Earl JW, Stephen KR, McLachlan AJ. Plasma protein distribution and its impact on pharmacokinetics of liposomal amphotericin B in paediatric patients with malignant diseases. Eur J Clin Pharmacol 2007;63:165-172
  3. Favaloro EJ, Lloyd J, Rowell J, Baker R, Rickard K, Kershaw G, Street A, Scarff K, Barrese G, Maher D, McLachlan AJ. A randomised cross-over, multi-centre study to compare the pharmacokinetics of two von Willebrand factor concentrates (Biostate® and AHF (High Purity)) in people with von Willebrand disorder. Thromb Haemost 2007; 97: 922–930
  4. Paradisis M, Jiang X, McLachlan AJ, Evans N, Kluckow M, Osborn D.Population pharmacokinetics and dosing regimen design of milrinone in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2007;92(3):F204-9.
  5. Bell JS, Aslani P, McLachlan AJ, Whitehead P, Chen TF. Mental health case conferences in primary care: Content and treatment decision making. Res Social Adm Pharm. 2007;3:86-103.
  6. Nath CE, McLachlan AJ, Shaw PJ, Coakley JC, Earl JW. Amphotericin B dose optimization in children with malignant diseases. Chemotherapy. 2007;53:142-7.
  7. Hilmer SN, McLachlan AJ, Le Couteur DG. Clinical pharmacology in the geriatric patient. Fundam Clin Pharmacol. 2007;21:217-230.
  8. Gurney H, Wong M, Balleine RL, Rivory LP, McLachlan AJ, Hoskins JM, Wilcken N, Clarke CL, Mann GJ, Collins M, Delforce SE, Lynch K, Schran H.Imatinib Disposition and ABCB1 (MDR1, P-Glycoprotein) Genotype. Clin Pharmacol Ther 2007;82:33-40.
  9. McLachlan AJ, Ramzan I, Milne RW. Frequently asked questions about generic medicines. Aust Prescr 2007;30:41–43
  10. Day RO, Graham GG, Hicks M, McLachlan AJ, Stocker SL, Williams KM. Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. Clin Pharmacokinet 2007;46:623-44.
  11. Hancock MJ, Maher CG, Latimer J, McLachlan AJ, Cooper CW, Day RO, Spindler MF, McAuley JH. Assessment of diclofenac or spinal manipulation therapy, or both, in addition to standard treatment for acute low back pain: a randomised controlled trial. Lancet 2007 ; 370(9599):1638-43.
  12. Favaloro EJ, Kershaw G, McLachlan AJ, Lloyd J. Time to think outside the box? Proposals for a new approach to future pharmacokinetic studies of von Willebrand factor concentrates in people with von Willebrand disease. Semin Thromb Hemost. 2007;33:745-58.
  13. Giam JA, McLachlan AJ, Krass I. Specialised compounding – practices and opinions of Australian community pharmacists. J Pharm Pract Res 2007; 37: 260-

2006

  1. Hong Y, Shaw PJ, Nath CE, Yadav SP, Stephen KR, Earl JW, McLachlan AJ. Population pharmacokinetics of liposomal amphotericin B in paediatric patients with malignant diseases. Anitmicrob Agents Chemother 2006;50 :935-42.
  2. McLachlan AJ, Ramzan I. Meals and medicines. Australian Prescriber 2006; 29: 40-42
  3. Paradisis M, Evans N, Kluckow M, Osborn D, McLachlan AJ. Pilot study of milrinone for low systemic blood flow in very preterm infants. J Pediatr. 2006;148:306-13.
  4. Wong M, Balleine RL, Blair EYL, McLachlan AJ, Ackland S, Garg M, Evans S, Farlow D, Collins M, Rivory LP, Hoskins JM, Clarke CL, Gurney H. Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer. J Clin Oncol 2006;24:2448-55.
  5. Katarzyna K. Loboz KK, Gross AS, Williams KM, Liauw WS, Day RO, Blievernicht J, Zanger UM, McLachlan AJ. CYP2B6 activity: effect of ethnicity and induction by rifampicin as measured by bupropion hydroxylation. Clin Pharmacol Ther 2006; 80:75-84.
  6. Bell JS, Whitehead P, Aslani P, McLachlan AJ, Chen TF. Drug-related problems in the community setting: pharmacists' findings and recommendations for people with mental illnesses. Clin Drug Investig. 2006;26:415-425.
  7. Ray JE, Keogh AM, McLachlan AJ. Decision support tool to individualize cyclosporine dose in stable, long-term heart transplant recipients receiving metabolic inhibitors: overcoming limitations of cyclosporine C2 monitoring. J Heart Lung Transplant. 2006;25:1223-1229.
  8. Jiang X, Blair EY, McLachlan AJ. Investigation of the effects of herbal medicines on warfarin response in healthy subjects: a population pharmacokinetic-pharmacodynamic modeling approach. J Clin Pharmacol. 2006; 46:1370-8.
  9. Gisev N, Bell JS, McLachlan AJ, Chetty M, Chen TF. Psychiatric Drug Use Among Patients of a Community Mental Health Service: Patterns and Implications. Disease Management & Health Outcomes. 14:369-376, 2006.
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