You are here: Home / About the Faculty / Faculty Staff / Academic Staff

Basil D Roufogalis

Professor of Pharmaceutical Chemistry: 1989- present ; Executive Director, Herbal Medicines Research and Education Centre: 2000- present

Qualifications

MPharm PhD DSc

Contact Details

University of Sydney
Phone: +61 2 9351 3391
Fax: +61 2 9351 4391
Email:
Room S341
Pharmacy Building A15
The University of Sydney
NSW 2006 Australia

Research Interests

  • Calcium translocating ATPase pumps and inhibitors
  • Multi drug resistance in cancer
  • Calcium regulation of cellular signalling by GTP-binding proteins
  • Mechanisms of herbal medicines
  • New therapeutic agents from medicinal herbs in pain, diabetes, hyperlipidemia and cancer
  • Herb-drug interactions

Students interested in these projects and who are Australian or NZ citizens or Australian permanent residents may apply to the Faculty for the W H and Elizabeth M Deane Pharmaceutical Fund postgraduate scholarship for research in direct pain relieving drugs (see www.pharm.usyd.edu.au/future_students/scholarships.shtml, closing October 31 2007.

  • The role of small G-proteins in cellular function. Our laboratory was the first to report the Ca2+/calmodulin sensitivity of a small G-protein, subsequently identified as Ral-A. The role of Ral-A in cellular function, particularly as a part of the exocyst complex involved in exo/endocytosis in neuronal cells has been reported for the first time and its physiological function has been investigated. Recent studies identified an additional binding partner, the redox sensitive protein Erp57, and extensive mutation studies on both Ral-A and the Erp57 are being used to identify the physiological significance of this interaction in neuronal cell function (joint project with the Children’s Medical Research Institute)
  • Overcoming multidrug resistance in cancer. The problem of multidrug resistance in cancer is responsible for failure of cancer chemotherapy. Projects have been undertaken to identify strategies for the reversal of this resistance, through detailed studies on the potential use of naturally occurring flavonoids to inhibit transport of drugs by P-glycoprotein, a protein pump overexpressed in resistant cells, including leukaemia cells. A new flavonoid has been identified as a potential new lead drug for reversing multidrug resistance, and is the subject of a PCT patent application. A second approach has been to investigate the mechanisms of traffic of P-glycoprotein in cells, using living cell fluorescence microscopy, with the aim of finding agents that can prevent the translocation of P-glycoprotein to the plasma membrane, where it pumps out the anticancer drugs. The interaction of P-glycoprotein with cytochrome P450 metabolic enzymes and their co-expression and functional interaction are being investigated (with Dr Mary Bebawy)
  • Development of new analgesic/antiinflammatory agents based on their interaction with the capsaicin (TRPV-1) receptor (with Dr Colin Duke). An industry/university funded ARC SPIRT (now Linkage) grant allowed the investigation of the interaction of certain derivatives of gingerols, the pungent principles found in ginger, with the TRPV-1 receptor from primary rat dorsal root ganglia and in in vitro cyclooxygenase 1 and –2 assays. A synthetic chimeric hybrid gingerol/capsaicin molecule was obtained as a lead compound for further development as a drug candidate. An extract of ginger enriched in a gingerol active metabolite has been developed as a potential commercial extract with the partner company. The pure compounds and extracts were found to have significant anti-pain activity in animal models, in both acute and chronic pain models. The new molecules and their novel activities were granted international PCT patents in the US and Australia. The mechanism of interaction of antinociceptive agents with TRPV1 and related thermoreceptors, and the mechanism of regulation of these receptors by inflammatory activators and cell signalling pathways are under investigation.
  • Development of cholesterol lowering agents. Research is being undertaken on a saponin fraction from the Chinese medicine Gynostemma pentaphyllum for development as an alternative medicine for the treatment of hypertriglyceridemia, high cholesterol and atherosclerosis, with minimum side effects. Chemical studies have identified new molecules with novel activities described for the first time against PPAR-alpha receptors in the liver and heart (with Dr Colin Duke and collaboration with a Chinese industry partner). The consequences of PPAR-alpha mediated gene transcription on downstream pathways (eg tissue factor and metalloproteinases) is being investigated (with Dr Yuhao Li)
  • Development of antidiabetic agents from Ayurvedic, Chinese and Western medicinal plants. A series of more than 12 recent publications in high impact journals has elucidated the mechanisms behind the traditional use of plants, including Punica granatum, Salacia oblonga, Panax notoginseng and a berry shoot extract in lowering glucose and improving glucose tolerance in various type-2 diabetes models. Furthermore, the ability of these extracts, and in some cases their isolated active constituents, has been investigated on preventing the complications of diabetes, including cardiac fibrosis and liver steatosis, using gene transcription and translation techniques together with functional studies. Important mechanisms elucidated include interaction with PPAR-gamma receptors, modulation of iNOS, NFκB and FATP genes and their protein products, and the alpha-glucosidase enzyme responsible for postprandial hyperglycemia (with Dr Yuhao Li and Dr George Li).
  • Immune-stimualtion to enhance the outcome of cancer chemotherapy. Recent introduction of the cancer immunology group of Dr Daniel Sze into my laboratory has led to various collaborative projects aimed at screening Chinese and other medicines for positive immune stimulating and cancer cell cytotoxic activity in multiple myeloma. Techniques of phytochemistry and cell based assays are being developed to progress these cancer cell biology studies.
Back to Top

Professional Employment Record

1968 - 1969 Postdoctoral Fellow, Department of Chemistry, Division of Biochemistry, University of Ottawa.

1969 - 1975 Assistant Professor and Medical Research Council of Canada Scholar, University of British Columbia, Vancouver, Canada.

1980 - 1989 Associate Professor and Professor, University of British Columbia, Vancouver.

1986 - 1989 NH&MRC Senior Research Fellow, University of Sydney.

1989 - 2005 Professor of Pharmaceutical Chemistry, University of Sydney.

1993 - 1995 Head of Department of Pharmacy, University of Sydney.

1997 - present Executive Director, Herbal Medicines Research and Education Centre, University of Sydney

2000 - present Pro Dean, Faculty of Pharmacy, University of Sydney

Back to Top

Professional Activities

1990 - 1997 Organiser and Chair, Sydney Signal Transduction Group

1990 - 1997 NHMRC Major Equipment Committee

1991, 1999 DSc Assessment Committees (ad hoc)

1992, 1995 Department of Pharmacology and Bill Walsh Cancer Research Laboratories Review Committees

1992 - 1995 Sydney University Macromolecualr Analysis Facility Committee (SUMAC, SUPAMAC)

1990 - 1993 Faculty of Science Research Committee

1995 - 1997 University Research Grants (URG) Committee

1992 - 1995 Faculty of Science Associate Professor Promotions Committee

1993 - 2004 Member, Pharmacy Research Trust Grants Committee

1995, 1997 Faculty of Science Chair and Personal Chair Selection Committees

2000 Faculty of Science U2000 Fellowship Committee

1997 Faculty of Science First Year Coordinator Selection Committee

1999 Small ARC Grants Committee

2001 - 2004 Central University Level D Senior Appointments Committee

2001 Pharmaceutics Chair Selection Committee

2002 - 2004 AMA Complementary Medicines Policy Advisory Committee (adviser)

2005/6 AMA Therapeutics Committee (adviser)

2005 Government Advisory Committee on the regulation of complementary medicine practitioners

2004/05 Consultant (EqiTX Pty Ltd)

2004/6 Consultancy Reports to Herbal Medicines Companies (various)

2007 Interim Consultative Committe, National Institute of Complementary Medicine

2007/8 Chair, Scientific Committee, 3rd International Congress Complementary Medicines Research

Back to Top

Recent Publications 2000-2008

  • Huang, Tom Hsun-Wei, Li, Yuhao; Razmoski-Naumovski, Valentina; Tran, Van Hoan; Li, George Qian; Duke, Colin C; and Basil D. Roufogalis. (2006). Gypenoside XLIX isolated from Gynostemm pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR alpha dependent pathway. Journal of Biomedical Science: 13:535-548.
  • Tom Hsun-Wei Huang, Van H Tran, Rujee K Duke, Sharon Tan, Sigrun Chrubasik, Basil D. Roufogalis, Colin C Duke. (2006). Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kB activation. Journal of Ethnopharmacology. 104:149-155.
  • Wen, Suping, Huang, Tom H.W. Li, George, Q. Yamahara, Johji, Basil D. Roufogalis, Li. Yuhao (2006). Bromelain improves decrease in defecation in postoperative rats: Modulation of colonic genes expression of inducible nitric oxide synthase. Life Sciences. 78:995-1002.
  • Huang, Tom Hsun-Wei, Tran, Van Hoan Roufogalis, Basil D. Li, Yuhao (2006). Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells. Toxicology and Applied Pharmacology. 218 (1): 30-36.
  • Mandadi, Sravan, Tominaga, Tomoko, Numazaki, Mitsuko, Murayana, Saito, Namie Naoaki , Armati, Patricia J., Roufogalis, Basil D., Tominaga, Makoto. (2006). Increased sensitivity of desensitized TRPV1 by PMA occurs through PKC-mediated phosphorylation at S800. Pain.123:106-116.
  • Tran VH, Kantharaji R, Roufogalis, B.D., Duke CC. (2006). An Efficient and Facile Synthesis of Capsaicin-Like Compounds as Agonist of TRPV1 Receptor. European Journal of Organic Chemistry. 13: 2970-2976.
  • Megalli S, Davies NM, Roufogalis, B.D. (2006) Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat. J. Pharmacy and Pharmaceutical Sciences. 9 (3): 281-291.
  • Riley LG, Roufogalis, B.D., Li GQ, Weiss AS. (2006). A radio assay for synaptic core complex assembly: screening of herbal extracts for effectors. Analytical Biochemistry 57:50- 57.
  • Qi JC, Wang J, Mandadi S, Tanaka K, Roufogalis BD, Madigan MC, Lia K, Yan F, Chong, BH, Stevens RL and Krilis SA (2006). Human and mouse mast cells use the tetraspanin CD9 as an alternate intrleukin 16 receptor. Blood 107 (1): 135-142.
  • Huang, Tom Hsun-Wei, Tran, Van Hoan, Roufogalis, Basil D., Li, Yuhao. (2007) Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells. Toxicology and Applied Pharmacology 218 (1): 30-36.
  • Fu D, Roufogalis, B.D. (2007). Actin Disruption Inhibits Endosomal Traffic of P-glycoprotein- EGFP and Resistance to Daunorubicin Accumulation. American Journal of Physiology (Cell Physiol)., 294 (4, Pt 1): C1543-C1552
  • Huang, Tom Hsun-Wei, Tran, Van Hoan, Roufogalis, B.D, Li, Yuhao, (2007). Gypenoside XLIX, a naturally-occuring PPAR-alpha activator, inhibits cytokine- induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells. European Journal of Pharmacology 565 (1-3): 158-165
  • Hesse, C., Razmovski-Naumovski, V., Duke, C.C., Davies, N.M., Roufogalis, B.D. (2007) Phytopreventive effects of Gynostemma pentaphyllum against acute indomethacin-induced gastrointestinal and renal toxicity in rats. Phytotherapy Research 21(6): 523-530.
  • Chrubasik, J.E., Roufogalis, B.D. and Chrubasik, S. (2007) Evidence of effectiveness of herbal anti-inflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain. Phytotherapy Research, 21(7): 675-683.
  • Chrubasik, Julia E., Roufogalis, Basil D., Wagner, Hidebert, Chrubasik, Sigrun A. (2007) A comprehensive review on nettle effect and efficacy profiles. Part 1: Herba urticae. Phytomedicine 14 (6): 423-435.
  • Chrubasik, J.E., Roufogalis, B.D., Wagner, H., Chrubasik, S. (2007) A comprehensive review of the stinging nettle effect and efficacy profiles. Part 11. Urticae radix. Phytomedicine 14 (7-8): 568-579.
  • Huang, T.H., He, L., Qin, Q., Yang, Q., Peng, G., Harada, M. Qi, Y. Yamahara, J., Roufogalis, B.D., Li, Y. (2007) Salacia oblonga root decreases cardiac hypertrophy in Zucker diabetic fatty rats: inhibition of cardiac expression of angiotensin II type 1 receptor.Diabetes, Obesity and Metabolism .10:7:574-585.
  • Fu, Dong, van Dam, Ellen M., Brymora, Adam, Duggin, Iain G., Robinson, Phillip J., Roufogalis, Basil D. (2007) The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein. Biochimica et Biophysica Acta 1773, 1062-1072.
  • Loh YSC, Suilin M, Brown RD, Yamagishi T, Yang S, Joshua DE, Ho P, Gibson J, Roufogalis BD, Sze D. (2007). Characteristics of 'side population' as the putative cancer stem cells in myeloma : Cell growth and differentiation capability. Molecular Cancer Therapeutics. 6:12: 3365s-3366s Part: Part 2.
  • Huang, T.H.W., Bebawy, M., Tran, V.H., Roufogalis, B.D. (2007) Specific reversal of multidrug resistance to colchicine in CEM/VLB100 cells by Gynostemma pentaphyllum extract. Phytomedicine.14: 830-839.
  • Goh, P., Sze, D.M., and Roufogalis, B.D. (2007). Molecular and Cellular Regulators of Cancer Angiogenesis. Current Cancer Drug Targets. 7(8):743-58.
  • Mandadi, S. and Roufogalis, B.D. (2007). ThermoTRP channels in nociceptors – taking a lead from capsaicin receptor TRPV1. Current Neuropharmacology. 6 (1): 21-38.
  • Li, Y, Qi., Huang, T.H., Yamahara, J., Roufogalis, B.D. (2008). Pomegranate flower: a unique traditional anti-diabetic medicine with dual PPAR-alpha/-gamma activator properties. Diabetes, Obesity and Metabolism. 10 (1): 10-17.
  • Chrubasik C, Roufogalis BD, Muller-Ladner U, Chrubasik S. (2008) A systematic review on the Rosa canina effect and efficacy profiles. Phytotherapy Research. 22 (6): 725-33.
  • Vlachojannis J, Roufogalis, BD, Chrubasik S. (2008) Systematic review on the safety of Harpagophytum preparations for osteoarthritic and low back pain, Phytotherapy Research. 22 (2): 149-52.
  • Valentina Razmovski-Naumovski; George G. Li ; Rujee K. Dukeª; Bruce N. Tattam, Basil D. Roufogalis; Colin C. Duke*. 2008. Current methods in the isolation and characterisation of saponins from Gynostemma pentaphyllum. Current Trends in Phytochemistry. In press
  • Andrew McLachlan, Mohi Iqbal Mohammed Abdul, Xuemin Jiang, Kenneth Williams, Ric Day, Basil Roufogalis, and Winston Liauw. (2008) "Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subject”. British Journal of Pharmacology.154:8:1691-1700.
  • Loh, Yen Sc; Mo, Suilin; Brown, Ross D; Yamagishi, Tetsuo; Yang, Shihong; Joshua, Douglas E; Roufogalis, Basil; Sze, Daniel Man-Yuen. (June 2008). “ Presence of Hoechst low side populations in multiple myeloma” . Leukemia and Lymphoma. 49:9:1813-1816.
  • Dedov, V.N. and Roufogalis, B.D. (2000) Mitochondrial calcium accumulation following activation of vanilloid (VR1) receptors by capsaicin in dorsal root ganglion neurons. Neuroscience 95, 183-188.
  • Monteith, G.R., Dedov, V.N. and Roufogalis, B.D. (2000) Calcium complexities: New fluorescence techniques for probing mitochondria and other subcellular compartments in Calcium: The Molecular Basis of Calcium Action in Biology and Medicine. (R. Pochet, R. Donato, J. Haiech, C. Heizmann and V. Gerke, Eds.), Kluwer Academic Publishers, The Netherlands. pp 697-713.
  • Monteith, G.R. and Roufogalis, B.D. (2000) Calcium signaling in hypertension: A focus on vascular smooth muscle cells. Electronic J. of Pathol. and Histol. 6, 001-99 .
  • Dedov, V.N., Cox, G.C. and Roufogalis, B.D. (2000) Visualisation of mitochondria in living neurons with single and two-photon fluorescence laser scanning microscopy. Micron 32(7), 653-660.
  • Chrubasik, S. and Roufogalis, B.D. (2000) Eds. Herbal Medicinal Products for the Treatment of Pain. Southern Cross University Press, Lismore, Australia.
  • Roufogalis, B. and Dedov, V. (2000) Capsaicin Receptor Mechanism and Future Trends for Analgesics. In: Chrubasik, S. and Roufogalis, B.D. Herbal Medicinal Products for the Treatment of Pain. Southern Cross University Press, Lismore, Australia, pp 94-99.
  • Dedov, V.N., Armati, P.J. and Roufogalis B.D. (2000) Three-dimensional organisation of mitochondrial clusters in regenerating dorsal root ganglion (DRG) neurons from neonatal rats: Evidence for mobile mitochondrial pools. Journal of the Peripheral Nervous System 5, 3-10.
  • Tjendraputra, E., Tran, V.H., Liu-Brennan, D., Roufogalis, B.D. and Duke, C.C. (2001) Effects of ginger constituents and synthetic analogues on cyclooxygenase-2 (COX-2) enzyme in intact cells. Bioorganic Chemistry 29, 156-163.
  • Brymora, A., Cousin, M.A., Roufogalis, B.D. and Robinson, P.J. (2001) Enhanced protein recovery and reproducibility from pull-down assays and immunoprecipitations using spin columns. Anal. Biochem. 295, 119-122.
  • Brymora, A., Valova, V.A., Larsen, M.R., Roufogalis, B.D. and Robinson, P.J. (2001) The brain exocyst complex interacts with RalA in a GTP-dependent manner: Identification of a novel mammalian Sec3 gene and a second Sec15 gene. J. Biol. Chem. 276, 29792-29797.
  • Koo, K.L.K., Ammit, A.J., Tran, V.H., Duke, C.C. and Roufogalis, B.D. (2001) Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation. Thrombosis Research. 103, 387-397.
  • Bebawy, M., Morris, M.B., and Roufogalis, B.D. (2002) Selective modulation of P-glycoprotein-mediated drug resistance. Br J Cancer. 85(12), 1998-2003.
  • Qi, J.C., Li, L., Wadley, R., Collins, A., Cooley, M., Naif, H.M., Nasr, N., Cunningham, A., Wanigasekara, Y., Roufogalis, B.D., Stevens, R.L. and Krilis, S.A. (2002) IL-16 regulation of human mast cells/basophils and their susceptibility to HIV-1. J. Immunol., 168, 4127-4134.
  • Chrubasik, S. and Roufogalis, B. (2002). Phytomedicines for respiratory tract diseases. Australian Pharmaceutical Publishing Company Ltd, Balmain, Australia.
  • Roufogalis, B.D. (2002) The growth in complementary and herbal medicine. In Modern Chinese Medicine: Education, Research and Development. (Kong Yun-cheung, Ed.), The Chinese University of Hong Kong, Hong Kong. pp 19-24.
  • Dedov,V.N., Tran, V.H., Duke, C.C., Connor, M., Christie, M.J., Mandadi, S. and Roufogalis, B.D. (2002) Gingerols: a novel class of vanilloid receptor (VR1) agonists. British Journal of Pharmacology, 137(6), 793-798.
  • Aktan, F., Henness, S., Roufogalis, B.D. and Ammit, A.J. (2003) Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF- κB-mediated iNOS protein expression. Nitric Oxide, 8, 235-242.
  • Wanigasekara, Y., Armati, P.J. and Roufogalis, B.D. (2003) Ca2+-ATPase isoforms are expressed in neuroprotection in rat, but not human, neurons. Neuro Report, 14, 2421-2424.
  • Pajic, M., Bebawy, M., Hoskins, J.M., Roufogalis, B.D. and Rivory L.P. (2004) Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines. Oncology Reports, 11(5), 1091-1095.
  • Li, G.Q., Duke, C.C. and Roufogalis, B.D. (2003) The quality and safety of traditional Chinese medicines. Australian Prescriber, 26(6), 128-130.
  • Fu, D., Bebawy, M., Kable, E.P.W. and Roufogalis, B.D. (2004) Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: Implications in multidrug resistance in cancer. Int J. Cancer, 109, 174-181.
  • Chrubasik, S., Conradt, C. and Roufogalis, B.D. (2004) Effectiveness of Harpagophytum extracts and clinical efficacy. Phytotherapy Research, 18, 187-189.
  • Nurtjahja-Tjendraputra, E., Ammit, A.J., Roufogalis, B.D., Tran, V.H. and Duke, C.C. (2003) Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thrombosis Research, 111(4-5), 259-265.
  • Jiang, X., Williams, K.M., Liauw, W., Ammit, A.J., Roufogalis, B.D., Duke, C.C., Day, R.O. and McLachlan, A.J. (2004) Effect of St John’s wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. British Journal of Clinical Pharmacology, 57(5), 592-599.
  • Mandadi, S., Numazaki, M., Tominaga, M., Bhat, M.B., Armati, P.J. and Roufogalis, B.D. (2004) Activation of protein kinase C reverses capsaicin-induced calcium dependent desensitization of TRPV1 ion channels. Cell Calcium, 35, 471-478.
  • Coxeter, P.D., McLachlan, A.J., Duke, C.C. and Roufogalis, B.D. (2004) Herb-drug interactions: an evidence based approach. Current Medicinal Chemistry, 11, 1513-1525.
  • Li, Y., Peng, G., Li, Q., Wen, S., Huang, T.H.-W., Roufogalis, B.D., Yamahara, J. (2004) Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese Zucker rates. Life Sciences, 75, 1735-1746.
  • Huang, T.H.W., Kota, B.P., Razmovski, V. and Roufogalis, B.D. (2005) Herbal or natural medicine as modulators of peroxisome proliferated activated receptors and related nuclear receptors for therapy of metabolic syndrome. Journal of Basic and Clinical Pharmacology and Toxicology, 96, 3-14.
  • Kota, B.P., Huang, T.H.W. and Roufogalis, B.D. (2005) An overview on biological mechanisms of PPARs. Pharmacological Research, 51(2), 85-94.
  • Jiang, X., Williams, K.M., Liauw, W.S., Ammit, A.J., Roufogalis, B.D., Duke, C.C., Day, R.O. and McLachlan, A.J. (2005) Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in health subjects. British Journal of Clinical Pharmacology (in press).
  • Huang, T.H.W., Peng, G., Kota, B.P., Li, G.Q., Yamahara, J., Roufogalis, B. and Li, Y. (2005) Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: role of lowering circulating lipids. British Journal of Pharmacology, 145(6), 767-774.
  • Huang, T.H.W., Peng, G., Kota, B.P., Li, G.Q., Yamahara, J, Roufogalis, B.D. and Li, Y. (2005) Anti-diabetic action of Punica granatum flower extract: activation of PPAR-γ and identification of an active component. Toxicology and Applied Pharmacology, 207, 160-169.
  • Li, Y., Wen, S., Kota, B.P., Peng, G., Li, G.Q., Yamahara, J. and Roufogalis, B.D. (2005) Punica granatum flower extract, a potent α-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. Journal of Ethnopharmacology, 99(2), 239-244.
  • Qi, J.C., Wang, J., Mandadi, S., Tanaka, K., Roufogalis, B.D., Madigan, M.C., Lai, K., Yan, F., Chong, B.H., Stevens, R.L. and Krilis, S.A. (2005) Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin 16 receptor. Blood, 6 Sept [Epub ahead of print].
  • Chrubasik, S., Pittler, M.H. and Roufogalis, B.D. (2005) Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine, 12, 684-701.
  • Huang, T.H.W., Razmovski-Naumovski, V., Salam, N.K., Duke, R.K., Tran, V.H., Duke, C.C. and Roufogalis, B.D. (2005) A novel LXR-alpha activator identified from Gynostemma pentaphyllum. Biochemical Pharmacology, 70(9), 1298-1308.
  • Wen, S., Huang, T.H.W., Li, G.Q., Yamahara, J., Roufogalis, B.D. and Li, Y. (2005) Bromelain improves postoperative ileus in rats: inhibition of inducible nitric oxide synthase and nuclear factor-kappaB activation. Life Sciences, 29 Aug [Epub ahead of print].
  • Huang, T.H.W., Yang, Q.L., Harada, M., Uberai, J., Radford, J., Li, G.Q., Yamahara, J., Roufogalis, B.D. and Li, Y. (2005) Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes. Toxicology and Applied Pharmacology, 210 (1-2), 78-85.
  • Huang, T.H.W., Peng, G., Li, G.Q., Yamahara, J., Roufogalis, B.D. and Li, Y. (2005) Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: activation of PPAR-alpha. Toxicology and Applied Pharmacology. 210 (3), 225 -235.
  • Megalli, S., Aktan, F., Davies, N.M. and Roufogalis, B.D. (2005). Phytopreventative anti-hyperlipidemic effects of gynostemma pentaphyllum in rats. Journal of Cardiovasc Pharmacol, 46 (6), 856-862.
  • Huang, T.H.W., Razmovski-Naumovski, V., Kota, B.P., Roufogalis, B.D. and Lin, D.S.H. (2005). The pathophysiological function of peroxisome proliferator-activated receptor-gamma in lung-related diseases. Respiratory Research, 6, 102.
  • Huang, T.H., Li Y., Razmovski-Naumovsi, V., Tran, V.H., Li, G.Q, Duke, C.C., Roufogalis, B.D. (2005). Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaβ activation via a PPAR-alpha-dependent pathway. J. Biomed. Sci. (2 September, accepted).
  • Razmovski-Naumovski V, Huang T.H.W, Tran V.H, Li G.Q, Duke C.C, Roufogalis B.D (2005) Chemistry and pharmacology of Gynostemma pentaphyllum. Phytochemistry Reviews, 4, 197–219.

    Huang, T.H.W, Tran, V.H., Duke, R.J, Tan, S., Chrubasik, S., Roufogalis B.D.and Duke C.C. (2006) Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF- kB activation. Journal of Ethnopharmacology, 104 (1-2),149-155.
  • Wen S, Huang T.H.W, Li G.Q, Yamahara J, Roufogalis B.D and Li Y (2006). Bromelain improves decrease in defecation in postoperative rats: Modulation of colonic gene expression of inducible nitric oxide synthase. Life Sciences, 78(9), 995-1002.
  • Tran, V.H., Kantharaj, R., Roufogalis, B.D. and Duke, C.C. (2006) An efficient and facile synthesis of Capsaicin-Like Compounds as Agonists of the TRPV1 Receptor. Eur. J. Org. Chem. 2970-2976
  • Mandadi S, Tominaga T, Numazaki M, Murayama N, Saito N, Armati PJ, Roufogalis BD, Tominaga, M (2006) Increased sensitivity of desensitized TRPV1 by PMA occurs through PKC-mediated phosphorylation at S800. Pain 123, 106-116

    Holland ML, Panetta JA, Hoskins JM, Bebawy M, Roufogalis BD, Allen JD, Arnold JC (2006). The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochemical Pharmacology, 71, 1146-1154
Back to Top

Recent Professional Publications 2000-2005

  • Duke, C.C. and Roufogalis, B.D. (2000) St John's Wort for depression comes of age. Australian Pharmacy Trade. 9 March, 26-27.
  • Duke, C.C. and Roufogalis, B.D. (2000) Echinacea for the relief of cold and flu symptoms. Australian Pharmacy Trade. 23 March, 26.
  • Duke, R.K., Duke, C.C., Johnston, G.A.R. and Roufogalis, B.D. (2000) Living fossil with modern applications. Australian Pharmacy Trade. 15 June, 26.
  • Chrubasik, S. and Roufogalis, B.D. (2000) Devil's claw eases osteoarthritic pain. Australian Pharmacy Trade, 21 April, 20.
  • Goh, P. and Roufogalis, B.D. (2001) Peppermint: a herb for calming irritable bowel? Australian Pharmacy Trade, 8 February, 22-21.
  • Chrubasik, S. and Roufogalis, B.D. (2001) Pain relief with herbal antirheumatics. New Zealand Pharmacy, 21, 19-24.
  • Chrubasik, S. and Roufogalis, B.D. (2001) Issues in quality and compatibility of herbal medicinal products. Australian Journal of Pharmacy, 82, 444-445.
  • Chrubasik, S. and Roufogalis, B.D. (2001) Issues in quality and comparability of herbal medicinal products. Australian Journal of Pharmacy, 82, 546-548.
  • Chrubasik, S. and Roufogalis, B.D. (2001) Chaste tree fruit for female disorders. Australian Journal of Pharmacy, 82, 156-157.
  • Goh, P. and Roufogalis, B.D. (2001) Feverfew for migraine prophylaxis. Australian Pharmacy Trade, 29 November, 18-19.
  • Goh, P. and Roufogalis, B.D. (2001) Horse chestnut seed extract for CVI. Australian Pharmacy Trade, 15 November, 16-18.
  • Chrubasik, S. and Roufogalis, B.D. (2001) Milk thistle fruit for liver diseases. Australian Pharmacy Trade, 11 December, 16.
  • Goh, P. and Roufogalis, B.D. (2002) Herbal therapies for peptic ulcers. Australian Pharmacy Trade, 7 February,
  • Goh, P. and Roufogalis, B.D. (2002) Glucosamine for osteoarthritis. Pharmacy News, 21 March,
  • Goh, P. and Roufogalis, B.D. (2002) Hawthorn efficacy tested as an aid for CHF. Pharmacy News, 16 May,
  • Goh, P. and Roufogalis, B.D. (2002) Ayurvedic herbal therapies for diabetes. Pharmacy News, 27 June,
  • Chrubasik, S. and Roufogalis, B.D. (2002) Efficacy and safety of topical capsaicin preparations. Australian Journal of Pharmacy, 83, 42-44.
  • Roufogalis, B.D and Chrubasik, S. (2002) Willow bark as good as NSAIDs for pain relief. Pharmacy News, 30 May.
  • Duke, R., Chebib, M., Duke, C., Johnson, G. and Roufogalis, B. (2002) Ginkgo biloba: food for the brain. New Zealand Pharmacy, 27-33, May.
  • Chrubasik, S. and Roufogalis, B. (2002) Effectiveness of herbal medicines: Where is the evidence? New Zealand Pharmacy, 31-33, December.
  • Coxeter, P.D., McLachlan, A.J., Duke, C.C. and Roufogalis, B.D. (2002) Valerian: Don’t be caught napping on the facts. Pharmacy News, 28 November, 14, 18.
  • Li, Q., Duke, C.C. and Roufogalis, B.D. (2002) The progress of Chinese medicine in Australia. In The Way Forward for Chinese Medicine. (Kelvin Chan and Henry Lee, Eds.), Taylor and Francis, London & New York. pp 173-189.
  • Coxeter, P.D., McLachlan, A.J., Duke, C.C. and Roufogalis, B.D. (2003) Interaction or over-reaction? Journal of Complementary Medicine, 2(1), 60-61.
  • Coxeter, P.D., McLachlan, A.J., Duke, C.C. and Roufogalis, B.D. (2003) St John's wort interactions. Journal of Complementary Medicine, 2(2), 66-68.
  • Coxeter, P.D., McLachlan, A.J., Duke, C.C. and Roufogalis, B.D. (2003) Ginkgo biloba interactions. Journal of Complementary Medicine, 2(3), 62-64.
  • Chrubasik, S., Roufogalis, B. (2003) Letter to the editor Re Strauss, Spine 2002; 27:2614-19. [Letter]. Spine, 28, 12, 1350-1351.
  • Coxeter, P.D., McLachlan, A.J., Duke, C.C. and Roufogalis, B.D. (2003) Ginseng interactions. The Journal of Complementary Medicine, 2(5):54-56.
  • Coxeter, P.D., McLachlan, A.J., Duke, C.C. and Roufogalis, B.D. (2003) Liquorice interactions. The Journal of Complementary Medicine, 2(4):40-42.
  • Coxeter, P.D. and Roufogalis, B.D. (2003) Move it: ginger extract for travel sickness. Pharmacy News, 4 September: 16c-18c.
  • Chrubasik, S. and Roufogalis, B.D. (2003) Hawthorn extract for heart complaints. Australian Journal of Pharmacy, 84, 825-826.
  • Chrubasik, S. and Roufogalis, B.D. (2003) Risk of adverse events during treatment with Kava extracts. Australian Journal of Pharmacy, 84, 597-598.
  • Chrubasik, S. and Roufogalis, B.D. (2003) Bioequivalence of Herbal Medicines. New Zealand Pharmacy, 53(6), 39-44.
  • Chrubasik, S. and Roufogalis, B.D. (2003) Echinacea for infectious conditions. Pharmacy News, April 3, 19c.
  • Chrubasik, S. and Roufogalis, B.D. (2003) Oral phytomedicines for the treatment of pain and inflammation. Pharmacy News, May 1, 14c-20c.
  • Chrubasik, S. and Roufogalis, B.D. (2003) Ginkgo extract for age-related macular degeneration. Australian Journal of Pharmacy, 84, 330.
  • Huang, H.-W., Kota, P., Li, Y., Goh, P. and Roufogalis, B.D. (2003) Clinical Review. Ayurveda: Tapping into India’s rich anti-diabetic pharmacopoeia. Pharmacy News, 26 June, 9-10.
  • Roufogalis, B.D. (2003) Editorial. The Journal of Complementary Medicine, 2.
  • Roufogalis, B.D. (2003) Herbal medicines in Pharmacy. News, Views, and Issues, China Education Centre Australia, November, 2.
  • Coxeter, P.D. and Roufogalis, B.D. (2003) Ginkgo biloba and age-related macular degeneration: Novel approach to management or blind hope? Pharmacy News, October 16, 11-12.
  • Kohlert-Schupp, C., McLachlan, A.J., Rich, C. and Roufogalis, B.D. (2005) Herbs in menopause. Journal of Complementary Medicine, 4(4), 50-56.
  • Megalli, S. and Roufogalis, B.D. (2005) Cholesterol lowering for healthy hearts: A herbal approach. The Australian Journal of Pharmacy, 86, 326-330.
Back to Top