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Daniela Traini

Senior Lecturer in Pharmaceutics

Qualifications

BSc (Hons) Milan PhD Bath

Contact Details

University of Sydney
Phone: +61 2 9351 2356
Fax: +61 2 9351 4391
Email:
Room 410
Badham Building A16
The University of Sydney
NSW 2006 Australia

Research Interests

General interests are into all areas of pharmaceutical technology and surface material science including: investigation into surface energy and particle interactions; characterisation and optimisation of pharmaceutical materials used in dry powder and pressurised metered dose inhalers; evaluation of controlled release formulations for both inhalation and other biological applications

Journal Articles

  1. Parlati, C. Buttini, F, Ammit, A.J., Young, P., Traini, D., Colombo, P. (2009) Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency. Pharmaceutical Research (Published online: 31 January 2009)
  2. Salama, R., Traini, D., Chan, H-K., Sung, A., Ammit, A.J., Young, P.M. (2009) Preparation and evaluation of controlled release microparticles for respiratory protein therapy. Journal of Pharmaceutical Science (Published Online: 7 Jan 2009)
  3. Young, P.M., Adi, H., Patel, J., Law, K., Rogueda, P., Traini, D. (2009) The influence of micronised particulates on the aerosolisation properties of pressurised metered dose inhalers. Journal of Aerosol Science, 40, 324 – 337.
  4. Hoe, S., Young, P.M., Chan, H-K, Traini, D. (2009) Introduction of the electrical Next Generation Impactor (eNGI) and investigation of its capabilities for the study of pressurised does inhalers. Pharmaceutical Research, 26, 2, 431 – 437.
  5. Young PM., Kwok, P., Adi, H., Chan, H-K, Traini D. (2008) Lactose composite carriers for respiratory delivery. Pharmaceutical Research, 26, 4, 802 – 810.
  6. Adi, S.; Adi, H.; Chan, H-K.; Young, P. M.; Traini, D.; Yang, R.; Yu, A. (2008) Scanning White-Light Interferometry as a Novel Technique to Quantify the Surface Roughness of Micron-Sized Particles for Inhalation. Langmuir; 24(19); 11307-11312.
  7. Traini D., Jones SA., Nguyen, K, Young PM. (2008) Microstructural analysis of porous composite materials: dynamic imaging of drug dissolution and diffusion through porous matrices. AAPS Journal, 10, 4, 560.
  8. Adi, S., Adi, H., Traini, D., Young, P.M., Chan, HK. (2008) Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35, 12–18.
  9. Salama, R., Traini, D., Chan, H-K., Young, P.M. (2008) Preparation and Characterisation of co-sprayed drug-polymer micro particles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosol. European Journal of Pharmaceutics and Biopharmaceutics, 70, 145-152.
  10. Hoe, S., Rogueda, P., Young, P.M., Traini, D. (2008) Determination of reference ultrasound parameters for model and hydrofluoroalkane propellants using High-Resolution Ultrasonic Spectroscopy. AAPS PharmSciTech, 9, 2, 605-611.
  11. Traini, D., Thielmann, F., F., Acharya, M., Jarring, K., Young, P.M. (2008) The Influence of Lactose Pseudo-polymorphic Form on Salbutamol Sulphate -Lactose Interactions in DPI Formulations. Drug Development and Industrial Pharmacy, 34, Issue 9, 992 – 1001.
  12. Salama, R., Hoe, S., Adi, H., Traini, D., Chan, H-K., Young, P.M. (2008) Preparation and Characterisation of co-sprayed drug-polymer micro particles for inhalation 1: influence of polymer concentration on physical and in vitro characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 69, 486-495.
  13. Jones, M.D., Young, P.M., Traini, D., Shur, J., Edge, S., Price, R. (2008) Pre-conditioning of micronised budesonide for inhalation therapy. International Journal of Pharmaceutics, 357, 314-317.
  14. Adi, H., Larson I., Chiou, H., Young, P.M., Traini, D., Stewart, P. (2008) Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios. Journal of Pharmaceutical Sciences. Vol 97, Issue 8, 3140-3152.
  15. Adi, H., Young, P.M., Chan, H.K, Stewart, P., Agus, H., Traini, D. (2008) Co-spray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences. Vol 97, Issue 8, 3356-3366
  16. Adi, H., Traini, D., Chan, HK., Young, P.M. (2008) The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. Journal of Pharmaceutical Science Vol 97, 7, 2780-2788.
  17. Young, P.M., Roberts, D., Chiou, G., Rae, W., Chan, H-K., Traini, D (2008) Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science Vol 39, 82-93.
  18. Young, P.M., Sung, A., Traini, D., Kwok, P., Chiou, H., Chan, H-K. (2007) Influence of humidity on the electrostatic charge and aerosol performance of dry powder carrier systems performance. Pharmaceutical Research, Vol 24, No 5, 963-970.
  19. Young, P.M., Tee, T., Chiou, H., Chan, H-K., Traini, D. (2007) The influence of mechanical processing dry powder inhaler carriers on drug aerosolisation performance. Journal of Pharmaceutical Sciences, Vol 96, No 5, 1331-1341.
  20. Young, P.M., Traini, D., Coates, M., Chan, H-K. (2007) Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter, Vol 394, 315-319.
  21. Young, P.M., Edge, S., Staniforth, J.N., Steele, D.F., Traini, D., Price, R. (2007) The effect of moisture on the functionality of modified starch 2: compressibility and compactability. Pharmaceutical Development and Technology, Vol 12, 217-222.
  22. Young, P.M., Chiou, H., Tee, T., Traini, D., Chan, H-K., Thielmann, F., Burnett, D. (2007) The use of organic vapour sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug Development and Industrial Pharmacy, Vol 33 Issue 1, 91-97.
  23. Traini, D., Young, P.M., Rogueda, P., Price, R. (2007) In vitro investigation of drug particulate interactions and aerosol performance of pressurised metered dose inhalers. Pharmaceutical Research, Vol 24, 125-135.
  24. Adi, H., Larson, I., Chiou, H., Young, P.M., Traini, D., Stewart, P. (2006) Dispersion of salmeterol xinofoate from powder mixtures for inhalation – the influence of fine lactose size on the mechanism of dispersion. Pharmaceutical Research, Vol 23, 2556-2565.
  25. Traini, D., Price, R., Young, P.M., Rogueda, P. (2006) A novel apparatus for the determination of solubility in pressurised metered dose inhalers. Drug Development and Industrial Pharmacy, Vol 32, 1159-1163.
  26. Traini, D., Young, P.M., Jones, M., Price, R., Edge, S. (2006) Comparative study of erythritol and lactose monohydrate as carriers for inhalation: atomic force microscopy and in vitro correlation. European Journal of Pharmaceutical Sciences, Vol 27, 243-251.
  27. Traini, D., Young, P.M., Rogueda, P., Price, R. (2006) The use of AFM and surface energy measurements to investigate drug-canister material interactions in pressurised metered dose inhalers. Aerosol Science & Technology, Vol 40, 1-10.
  28. Traini, D., Price, R., Young, P.M., Rogueda, P. (2006) Investigation into the influence of polymeric stabilising excipients on the performance of pressurised metered dose inhalers. International Journal of Pharmaceutics, Vol 320, 58-63.
  29. Traini, D., Rogueda, P., Young, P.M., Price, R. (2005) Surface energy and interparticle force correlation in model pMDI formulations. Pharmaceutical Research Vol 22, 816-825.
  30. Young, P.M., Edge, S., Traini, D., Jones, M.D., Price, R., Sabawi, D., Urry, C., Smith C. (2005) The influence of dose on the performance of dry powder inhalation systems. International Journal of Pharmaceutics, Vol 296, 26-33.
  31. Young, P.M., Price, R., Lewis, D., Edge, S., Traini, D. (2003) Under pressure: Predicting pressurised metered dose inhaler interactions using the atomic force microscope. Journal of Colloid and Interface Science. Vol 262, 298-302.
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Reviews

  1. Rogueda, P. and Traini, D. (2007) The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects. Expert Opinion in Drug Delivery Vol 4, Number 6, 595-606 (12).
  2. Rogueda, P. and Traini, D. (2007) The nanoscale in pulmonary delivery. Part 2: formulation platforms. Expert Opinion in Drug Vol 4, Number 6, 607-620 (14).
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Book Chapters

  1. Young, PM., Edge, S., Traini, D. (2007) Enhanced pulmonary therapy. In: Advanced Drug Formulation Design to Optimize Therapeutic Outcomes by Robert O. Williams III (Editor), David R. Taft (Editor), Jason T. McConville (Editor) Publisher: Informa Healthcare, 1-52.
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Patent

Young, P.M., Chan, H-K., Traini, D. (2007) Composite carriers for dry powder inhalation therapy. International PCT Filed N. W/O 2008/134817

Colombo, P., Young, P.M., Traini, D. (2008) A drug powder for inhalation administration and a process thereof. International PCT Filed

Other referenced publications

  1. Traini, D., Loreti, G., Jones, A., Young, P.M (2008) X-Ray micro-computed tomography: novel application to investigate modified release systems. Microscopy and Analysis (January, Issue 61)
  2. Chan, H-K., Young, P.M., Traini, D., Coates, M. (2007) Dry Powder Inhalers: Challenges and Goals for Next Generation Therapies. Pharmaceutical Technology Europe. (April Issue).

In excess of 30 papers in refereed conference proceedings and 8 invited podium presentations