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Professor Iqbal Ramzan

Dean
Professor of Pharmacy

Contact Details

University of Sydney
EA to the Dean (Phone): + 61 2 9351 2077
Fax: + 61 2 9351 6950
Email:
Room S322
Pharmacy Building A15
The University of Sydney
NSW 2006 Australia

Biographical Profile

Professor Ramzan obtained his undergraduate training in Pharmacy in New Zealand and his post-graduate training from the Department of Pharmacy at The University of Sydney where he obtained his Master of Science and PhD degrees specialising in Drug Pharmacokinetics and Pharmacodynamics.

Professor Ramzan spent five years at the State University of New York at Buffalo in the Department of Pharmaceutics where he carried out postdoctoral training under the guidance of Distinguished Professor Gerhard Levy. He also held Faculty appointment at the same institution and also was Assistant Professor of Pharmaceutical Sciences at the School of Pharmacy at the University of Pittsburgh. Professor Ramzan returned to Australia in 1989 where he has held academic positions as Lecturer, Senior Lecturer, Associate Professor and now as Professor.

Professor Ramzan is an author/co-author of 100 research publications mainly in the areas of pharmacokinetics, pharmacodynamics, drug assays and drug metabolism.

In 2000 Professor Ramzan was appointed an Associate Dean in the Faculty of Pharmacy, The University of Sydney, with responsibility for admissions. Professor Ramzan is a registered pharmacist.

In June 2005 Professor Ramzan was appointed Acting Dean and is currently the Dean of Pharmacy. In December 2005 Professor Ramzan commenced his 18 month term as Fellow of University of Sydney Senate elected by the University's academic staff.

In February 2008 Professor Ramzan was formally appointed Dean of the Faculty of Pharmacy.

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Research Interests

Pharmacokinetics and pharmacodynamics of drugs with particular interest in drug pharmacogenetics. Pharmacological and adverse effects of herbal medicines.

Recent Grant Support

  • ARC LIEF (LE0883030)
    Title: High-Resolution Field Emission Scanning Electron Microscopy (FESEM) Platform for Characterisation at the Nanometre-Level
    CI’s: Cairney JM, Ringer SP, Braet FC, Ferry M, Sorrell CC, Ye L, Ruys AJ, Barton GW, Harris AT, Ranzi G, Eggelton BJ, Grillet C, McKenzie DR, Lay PA, Masters AF, Parker AR, Overall RL, Weiss AS, Murphy CR, Ramzan IM, Copeland LJ and Potts DT; Funds: $450,000
  • ARC LIEF (LE0 883036)
    Title: Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological Materials, and Medical Research
    CI’s: Lay PA, McNaughton D, Maschmeyer T, Potts DT, Swain MV, Grau GE, Sorrell TC, Ramzan IM, Beardall J, Bernard CC, Marshall CP, Dutkiewicz A, Penny DA, Wood BR, Yang W, Soon L, Traini D and Carter EA; Funds: $400,000
  • ARC LIEF 2007 (LE0775598)
    Title: High-Resolution Transmission Electron Tomographic Facility for Nanoanalytical Characterisation in the Life and Material Sciences
    CI’s: Braet FC, Ringer SP, Soon L, Liu Z, Hambley TW, Lay PA, Warr GG, Thordarson P, Murphy CR, Dos Remedios CG, Weiss AS, Overall RL, Parker AR, Ramzan IM, Cunningham AL, Young PM, Copeland LJ, Munroe PR, Stevens-Kalceff MA, Gaus K and Gooding JJ; Funds: $1,000,000
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Recent Peer-Reviewed Publications

  • Zhang WV, Ramzan I and Murray M. Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis. Journal of Pharmacology and Experimental Therapeutics, 2007 322: 770-777.
  • McLachlan AJ, Ramzan I and Milne RW. Frequently asked questions about generic medicines. Australian Prescriber, 30, 41-43, 2007. Letter in response – Australian Prescriber 30: 4, 88-89, 2007.
  • Witkram L, Maat B, Ramzan I. Ginkgo biloba in Alzheimer’s disease: Bilobalide as an acetylcholinesterase inhibitor. Phytopharmacology and Therapeutic Values III, Recent Progress in Medicinal Plants, Vol 21, Ch25, 411-413, 2007.
  • Fu S, Korkmaz E, Braet F, Ngo Q and Ramzan I. The influence of kavain on hepatic ultrastructure. World Journal of Gasteroenterology, 14, 541-547, 2007.
  • Ramzan I, Cohn G and Fu S. Kava in the treatment of alcoholism and other diseases. The Encyclopaedia of Botanicals in Clinical Practice, In Press, 2007.
  • Young AM, Ramzan I and McLachlan A. Dose Administration Aids: Issues related to dose form stability and repackaging. Journal of Pharmacy Practice and Research, Under Revision, 2007.

Publication List

2005 - 2007

  • McLachlan AJ, Ramzan I and Milne RW. Frequently asked questions about generic medicines. Australian Prescriber; In Press (2007)
  • Witkram L, Maat B, Ramzan I. Ginkgo Biloba in Alzheimer’s Disease: Bilobalide as an Acetylcholinesterase Inhibitor. Recent Progress in Medicinal Plants, 21: 138-150, 2006
  • Ramzan I and McLachlan A. Anti-epileptics switching problem?... but where is the evidence? The Australian Journal of Pharmacy 86:772&820, 2005
  • Anke J, Fu S, and Ramzan I. Kavalactones fail to inhibit alcohol dehydrogenase in vitro. Phytomedicine, 13:192-195, 2005
  • Ramzan I and McLachlan A. Generic arguments. Australian Pharmacist, 24:501-502, 2005
  • McLachlan A and Ramzan I. Meals and medicines. Australian Prescriber, 29:40-42, 2006
  • Obligacion R, Murray M, Ramzan I. Drug Metabolising Enzymes and Transporters: Expression in the Human Prostate and Roles in Prostate Drug Disposition. Journal of Andrology, 27:138-150, 2006

2004

  • Pearce G, McLachlan A, Ramzan I. Bioequivalence: How, Why, and What Does it Really Mean?Journal of Pharmacy Practice and Research, 34:195-200, 2004
  • O'Halloran PL, Hosseini-Yeganeh M, McBride LJ and Ramzan I. Onset and offset pharmacodynamics of propofol. Die Pharmazie, 59: 76-77, 2004.
  • Tran VH and Ramzan I. Chemistry of Kava and Kavalactones. In: Kava from Ethnology to Pharmacology. YN Singh Ed., CRC Press (Boca Raton, 2004), pp.76-103.
  • Anke J and Ramzan I. Kava hepatotoxicity: Are we any closer to the truth? Planta Medica, 70:193-196, 2004.
  • Anke J and Ramzan I. Pharmacokinetic and pharmacodynamic drug interactions with kava (Piper methysticum Forst. f). Journal of Ethnopharmacology, 93:153-160, 2004.
  • Hong Y, Ramzan I and McLachlan AJ. Disposition of amphotericin B in the isolated perfused rat liver. Journal of Pharmacy and Pharmacology. 56: 35-41, 2004
  • Download a full list of the Publications

2000 - 2003

  • Ling G, Ramzan I and Baker B. Rocuronium infusion requirements and plasma concentrations at constant levels of neuromuscular paralysis during three phases of liver transplantation. Journal of Clinical Anesthesia, 15: 257-266, 2003.
  • O'Halloran PL, Hosseini-Yeganeh M, McBride LJ and Ramzan I. Onset and offset pharmacodynamics of propofol. Die Pharmazie, In Press.
  • Yeganeh MH and Ramzan I. Pharmacokinetics of H2-antagonists during propofol or thiopentone anaesthesia in rats. Indian Journal of Pharmacology, 34: 56-58, 2002.
  • Gao L, Ramzan I and Baker B. Rocuronium plasma concentrations during three phases of liver transplantation: relationship with early postoperative graft liver function. British Journal of Anaesthesia, 88: 764-770, 2002.
  • Sasongko L, Ramzan I, Williams KM and McLachlan AJ. Muscle distribution of the neuromuscular blocker gallamine using microdialysis. Journal of Pharmaceutical Sciences, 91: 769-775, 2002.
  • Rana J, Ramzan I and Baker AB. In vitro neuromuscular effects of droperidol in rats. Die Pharmazie, 4: 426, 2001.
  • Gao L, Ramzan I and Baker B. Neuromuscular paralysis as a pharmacodynamic probe to assess organ function during liver transplantation surgery. Journal of Clinical Anesthesia, 12:615-620, 2001.
  • Sasongko L, Ramzan I, Williams KM and McLachlan AJ. Application of a HPLC assay for the neuromuscular blocker gallamine to analysis of rat plasma, muscle and microdialysis samples. Journal of Chromatography B, 754: 467-475,2001.
  • Gao L, Ramzan I and Baker B. Gas chromatographic-mass spectrometric (GC-MS) assay for rocuronium and its metabolite, 17-desacetyl-rocuronium in human plasma. Journal of Chromatography B 757: 207-214, 2001.
  • Gao L, Ramzan I and Baker B. Potential use of pharmacological markers to quantitatively assess liver function during liver transplantation surgery. Anaesthesia and Intensive Care, 28: 375-385, 2000.
  • Nguyen A and Ramzan I. In vitro response of neuromuscular blockers after chronic carbamazepine treatment in rats. Die Pharmazie, 55: 957, 2000.
  • Sasongko L, Williams KM, Ramzan I, and McLachlan AJ. Assessment of in vitro and in vivo recovery of gallamine using microdialysis probe. Journal of Pharmacological and Toxicological Methods, 44: 519-525, 2000.

1990-1999

  • Turner RJ, Kam PCA, Ramzan I and Santilli MB. Effect of haemorrhage on plasma propofol concentrations in a patient undergoing orthotopic liver transplantation. British Journal of Anaesthesia, 83: 346-348, 1999.
  • Sawyer CA, Baker AB, Ramzan I and Regaglia F: Droperidol elimination after cardiopulmonary bypass surgery. Journal of Clinical Pharmacology, 38: 160-165, 1998.
  • Ramzan I, Goldsmith R and Burke W: A novel substance associated with gallamine-induced myoclonus. NeuroReport, 9: 1349-1352, 1998.
  • Turner RJ, Gatt SP, Kam PCA, Ramzan I and Daley M. Administration of a crystalloid fluid preload does not prevent the decrease in arterial blood pressure following induction of anaesthesia with propofol and fentanyl. British Journal of Anaesthesia, 80: 737-741, 1998.
  • Nguyen A and Ramzan I: In vitro neuromuscular effects of valproic acid. British Journal of Anaesthesia, 78: 197-200, 1997.
  • Nguyen A and Ramzan I: Acute in vitro effects of carbamazepine and carbamazepine-10,11-epoxide. Anesthesia and Analgesia, 84:886-890, 1997.
  • Yeganeh MH and Ramzan I: Determination of propofol in rat whole blood and plasma by high-performance liquid chromatography. Journal of Chromatography B, 691: 478-482, 1997.
  • Thompson JF, Eksborg S, Kam PCA, Ingvar C, Yau DF, Lai DTM and Ramzan I: Determinants of acute regional toxicity following isolated limb perfusion for melanoma. Melanoma Research, 6: 267-271, 1996.
  • Shanks CA and Ramzan I: Pharmacological interference with neuromuscular transmission. In: Foundations of Anaesthetics and Acute Medical Care Series: Foundations of Neuromuscular Transmission. Ed: Booij LHDJ, BMJ Publishing Group, London, pp. 58-79, 1996.
  • Rana J and Ramzan I: Neuromuscular blocking drug pharmacodynamics after chronic exposure to H2-antagonists. In vivo, 9: 163-166, 1995.
  • Nguyen A and Ramzan I: Acutely administered carbamazepine potentiates atracurium and suxamethonium paralysis in rats. Pharmaceutical and Pharmacological Letters, 5: 63-65, 1995.
  • Weekes LM, Keneally JP, Goonetilleke PH and Ramzan I: Pharmacokinetics of alcuronium in children with acyanotic and cyanotic cardiac disease undergoing cardiopulmonary bypass surgery. Paediatric Anaesthesia, 5: 369-374, 1995.
  • Thompson JF, Kam PCA, Ramzan I and Yau DF: Clinical pharmacokinetics of melphalan in isolated limb perfusion: compartmental modelling and moment analysis. Regional Cancer Treatment, 8: 83-87, 1995.
  • Mishra Y, Torda T, Ramzan I and Graham G: In vitro interaction between H2-antagonists and vecuronium. Journal of Pharmacy and Pharmacology, 46: 205-208, 1994.
  • Fu C, Mishra Y and Ramzan I: Omeprazole potentiates atracurium and succinylcholine paralysis in vivo in rats. Anesthesia and Analgesia, 78: 527-530, 1994.
  • Craig AJ, Ramzan I and Malik R: Pharmacokinetics of fluconazole in the cat following intravenous and oral administration. Research in Veterinary Science, 57: 372-376, 1994.
  • Heffernan D and Ramzan I: Acute in vivo pharmacodynamic interaction of phenytoin and its metabolite, p-HPPH with neuromuscular blockers in rats. Pharmaceutical and Pharmacological Letters, 3: 209-212, 1994.
  • Mishra Y and Ramzan I: Interaction between succinylcholine and ranitidine in rats. Canadian Journal of Anaesthesia, 40: 32-37, 1993.
  • Mishra Y and Ramzan I: Ranitidine reverses gallamine paralysis in rats. Anesthesia and Analgesia, 76: 627-630, 1993.
  • Keneally JP, Goonetilleke PH and Ramzan IM: Delayed onset of alcuronium effect in children with cyanotic congenital heart disease. Anaesthesia and Intensive Care, 21: 197-200, 1993.
  • Ramzan IM, Keneally JP and Goonetilleke PH: Disposition and efficacy of alcuronium in young children undergoing elective surgery. Paediatric Anaesthesia, 3: 235-238, 1993.
  • Ramzan I, Wong BK and Corcoran GB: Pain sensitivity in dietary-induced obese rats. Physiology and Behaviour, 54: 433-435, 1993.
  • Mishra Y and Ramzan I: Interaction between famotidine and neuromuscular blockers. An in vivo study in rats. Anesthesia and Analgesia, 77: 780-783, 1993.
  • Hamdan W and Ramzan I: Effect of fluconazole on neuromuscular transmission. In vivo, 7: 461-462, 1993.
  • Ramzan I and Chan M: Influence of fluconazole on antipyrine kinetics in rats. European Journal of Drug Metabolism and Pharmacokinetics, 18: 273-276, 1993.
  • Burke W and Ramzan I: Myoclonus in the decerebrate cat produced by gallamine. Brain Research, 580: 189-196, 1992.
  • Mishra Y and Ramzan I: Interaction between succinylcholine and cimetidine in rats. Canadian Journal of Anaesthesia, 39: 370-374, 1992.
  • Mishra Y and Ramzan I: Enhancement by cimetidine of neuromuscular paralysis induced with atracurium in rats. Archives Internationales de Pharmacodynamie et de Therapie, 318: 97-106, 1992.
  • Mishra Y and Ramzan I: Potentiation of gallamine-induced neuromuscular paralysis in vivo in rats by intravenous cimetidine. Clinical and Experimental Pharmacology and Physiology, 19: 803-807, 1992.
  • Mishra Y and Ramzan I: Influence of cimetidine and ranitidine on gallamine disposition and neuromuscular pharmacodynamics in rats. Pharmaceutical and Pharmacological Letters, 2: 169-172, 1992.
  • Ramzan IM: High performance liquid chromatographic assay for laudanosine in biological fluids/tissues suitable for neurotoxic studies in rats. Journal of Chromatography Biomedical Applications, 565: 465-470, 1991.
  • Ramzan IM: High performance liquid chromatographic method for the determination of CHEB, a convulsant barbiturate in rat biological fluids. Journal of Pharmaceutical and Biomedical Analysis, 9: 777-779, 1991.
  • Ramzan IM: Pharmacodynamics of CHEB, a convulsant barbiturate, in acute renal failure. Medical Science Research, 19: 487-488, 1991.
  • Ramzan I: Pharmacodynamics of phenytoin induced ataxia in rats. Epilepsy Research, 5: 80-83, 1990.
  • Ramzan IM: 4-Methylpyrazole increases pentylenetetrazol convulsant concentrations in rats. Medical Science Research, 18: 405-406, 1990.
  • Ramzan IM: Theophylline neurotoxicity is unaffected by glycerol-induced renal failure. Pharmacology Biochemistry and Behaviour, 37: 583-585, 1990.
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1980-1989

  • Ramzan I: Proconvulsant effect of papaverine on theophylline-induced seizures in rats. Clinical and Experimental Pharmacology and Physiology, 16: 425-427, 1989.
  • Law SC, Ramzan IM, Brandom BW and Cook DR: Intravenous ranitidine antagonizes intense atracurium-induced neuromuscular blockade in rats. Anesthesia and Analgesia, 69: 611-613, 1989.
  • Ramzan IM and DeDonato V: Effect of nicotinamide on theophylline seizures in rats. Biochemical Pharmacology, 37: 1173-1174, 1988.
  • Ramzan IM and DeDonato V: Theophylline neurotoxicity in pregnant rats. Life Sciences, 42: 491-495, 1988.
  • Ramzan IM and DeDonato V: Effect of age on theophylline neurotoxicity in rats. AGE, 11: 94-96, 1988.
  • Ramzan IM: Lack of proconvulsant action of acute aspirin with pentylenetetrazol in rats. Medical Science Research, 16: 409-410, 1988.
  • Ramzan IM: Effect of cyclosporine on phenobarbital hypnotic concentrations in rats. Journal of Pharmaceutical Sciences, 77: 996-997, 1988.
  • Ramzan I and Levy G: Effect of acute liver dysfunction on the convulsant activity of pentylenetetrazol in rats. Medical Science Research, 16: 709-710, 1988.
  • Ramzan I and Levy G: Experimental renal dysfunction increases pain sensitivity in rats. Medical Science Research, 16: 995-996, 1988.
  • Shanks C, Ramzan I and Triggs E: Steady-state disposition and neuromuscular pharmacodynamics of gallamine in dogs. Medical Science Research 16: 735-736, 1988.
  • Ramzan I, Shanks C and Triggs E: Gallamine whole animal and vascularly isolated limb neuromuscular pharmacodynamics in anaesthetized dogs. Medical Science Research, 16: 747-749, 1988.
  • Ramzan IM and Levy G: Risk factors associated with theophylline-induced seizures. Medical Science Research, 16: 657-662, 1988.
  • Ramzan IM: 4-Methylpyrazole alters phenobarbital hypnotic concentrations in rats. Journal of Pharmacy and Pharmacology, 40: 817-818, 1988.
  • Ramzan IM: High performance liquid chromatographic determination of chemical convulsant pentylenetetrazol in serum, cerebrospinal fluid and rat brain. Journal of Chromatography Biomedical Applications, 432: 370-374, 1988.
  • Ramzan IM, Yasuhara M and Levy G: Kinetics of drug action in disease states. XIX. Effect of experimental liver disease on the neurotoxicity of theophylline in rats. Journal of Pharmacology and Experimental Therapeutics, 241: 236-238, 1987.
  • Ramzan IM: Determination of neuromuscular blocking drug gallamine in rat serum using high performance liquid chromatography. Journal of Chromatography Biomedical Applications, 417: 428-432, 1987.
  • Ramzan IM: Pharmacokinetic analysis of succinylcholine-cimetidine interaction. Anesthesia and Analgesia, 66: 1346, 1987.
  • Ramzan IM and DeDonato V: Lack of proconvulsant action of aspirin with theophylline in rats. Medical Science Research, 18: 1127, 1987.
  • Ramzan IM and Levy G: Kinetics of drug action in disease states. XVII. Effect of experimental renal failure on the pharmacodynamics of theophylline-induced seizures in rats. Journal of Pharmacology and Experimental Therapeutics, 240: 584-588, 1987.
  • Ramzan IM and Levy G: Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats. Journal of Pharmaceutical Sciences, 236: 708-713, 1986.
  • Ramzan IM and Levy G: Chronic theophylline administration has no apparent effect on theophylline concentrations required to produce seizures in rats. Proceedings of the Society for Experimental Biology and Medicine, 182: 176-180, 1986.
  • Ramzan IM: Succinylcholine in peripartum patients. Anesthesiology, 65: 441-442, 1986.
  • Ramzan IM: Pharmacokinetic basis for the dose-dependent decline in the neuromuscular blocking effect of gallamine. Anesthesiology, 63: 226-227, 1985.
  • Ramzan IM and Levy G: Kinetics of drug action in disease states XIV. Effect of infusion rate on pentylenetetrazol concentrations in serum, brain and cerebrospinal fluid of rats at onset of convulsions. Journal of Pharmacology and Experimental Therapeutics, 234: 624-628, 1985.
  • Ramzan IM and Levy G: Kinetics of drug action in disease states XV. Effect of pregnancy on the convulsive activity of pentylenetetrazol in rats. Journal of Pharmaceutical Sciences, 74: 1233-1235, 1985.
  • Chou RC, Ramzan IM and Levy G: Effect of pregnancy or renal dysfunction on differences in plasma protein binding of phenytoin in peripheral blood and blood exiting the liver of rats. International Journal of Pharmaceutics, 18: 217-221, 1984.
  • Shanks CA, Ramzan IM, Walker JS and Brown KF: Disposition of gallamine in patients undergoing open heart surgery involving cardiopulmonary bypass. Clinical Pharmacology and Therapeutics, 33: 792-799, 1983.
  • Ramzan IM, Shanks CA and Triggs EJ: Relationship between gallamine plasma concentration and neuromuscular paralysis in surgical patients. Journal of Clinical Pharmacology, 23: 243-251, 1983.
  • Ramzan IM: Rate of recovery from fazadinium: Relationship to the rate of decline of its plasma concentration. Journal of Pharmaceutical Sciences, 72: 1369-1370, 1983.
  • Ramzan IM: Molecular weight of cation as determinant of speed of onset of neuromuscular blockade. Anesthesiology, 57: 247-248, 1982.
  • Ramzan IM, Somogyi AA, Walker JS, Shanks CA and Triggs EJ: Clinical pharmacokinetics of non-depolarizing muscle relaxants. Clinical Pharmacokinetics, 6: 25-60, 1981.
  • Shanks CA, Walker JS, Ramzan IM and Triggs EJ: Dose response curves for four neuromuscular blockers using continuous i.v. infusion. British Journal of Anaesthesia, 53: 627-633, 1981.
  • Ramzan IM, Shanks CA and Triggs EJ: Gallamine disposition in surgical patients with chronic renal failure. British Journal of Clinical Pharmacology, 12: 141-147, 1981.
  • Ramzan IM, Shanks CA and Triggs EJ: Pharmacokinetics and pharmacodynamics of gallamine triethiodide in patients with total biliary obstruction. Anesthesia and Analgesia, 60: 289-296, 1981.
  • Ramzan IM, Shanks CA and Triggs EJ: Gallamine cumulation ratios. Anesthesia and Analgesia, 60: 912, 1981.
  • Ramzan IM, Triggs EJ and Shanks CA: Pharmacokinetic studies in man with gallamine triethiodide. I. Single and multiple clinical doses. European Journal of Clinical Pharmacology, 17: 135-143, 1980.
  • Ramzan IM, Triggs EJ and Shanks CA: Pharmacokinetic studies in man with gallamine triethiodide. II. Single 4 and 6 mg/kg i.v. doses. European Journal of Clinical Pharmacology, 17: 145-152, 1980.
  • Shanks CA, Somogyi AA, Ramzan IM and Triggs EJ: Tubocurarine and pancuronium: A pharmacokinetic view. Anaesthesia and Intensive Care, 8: 4-12, 1980.
  • Shanks CA, Ramzan IM and Triggs EJ: Two-vs three-compartment model for analysis of d-tubocurarine pharmacokinetics. Anesthesiology, 52: 375-376, 1980.
  • Ramzan IM, Shanks CA and Triggs EJ: The pharmacokinetics of d-tubocurarine administered by combined bolus and infusion. British Journal of Anaesthesia, 52: 375-376, 1980
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1978-1980

  • Ramzan IM, Shanks CA and Triggs EJ: The pharmacokinetics of d-tubocurarine administered by combined bolus and infusion. British Journal of Anaesthesia, 52: 375-376, 1980
  • Shanks CA, Ramzan IM and Triggs EJ: Studies in man with a constant-rate i.v. infusion of tubocurarine. Anaesthesia and Intensive Care, 7: 209-214, 1979.
  • Ramzan IM, Shanks CA and Triggs EJ: Studies of d-tubocurarine pharmacokinetics in humans and dogs. Anaesthesia and Intensive Care, 6: 30-35, 1978.
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