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Srinivas Nammi

SESQUI Research Fellow, Pharmacy

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Qualifications

B.Pharm, M.Pharm, PhD

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Contact Details

University of Sydney
Phone: +61 2 9351 4698; +61 2 9351 4436
Fax: +61 2 9351 4391
Email:
Room N265
Pharmacy Building A15
The University of Sydney
NSW 2006 Australia

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Professional Profile

Dr Srinivas Nammi has completed all his academic degrees at Andhra University, in the Faculty of Pharmaceutical Sciences, India. Dr Nammi was awarded GATE Fellowship by the Ministry of Human Resource, Government of India, to complete his postgraduate degree by research in Pharmacology. He worked for one year as a Pharmacologist in Chemiloids, an herbal drug company in India wherein he closely associated with the establishment of a Pharmacology research laboratory. Dr Nammi was also awarded Senior Research Fellowship by the Council of Scientific and Industrial Research (CSIR), Government of India, to pursue his PhD studies in Pharmacology. After completion of his PhD in 2003, Dr Nammi was awarded DAAD Scholarship to pursue his postdoctoral training in Germany at the Institute of Physiology, University of Tuebingen. Later on, to strengthen his research expertise he moved to Canada and worked as a postdoctoral fellow at the Section of Endocrinology and Metabolism, Department of Internal Medicine, University of Manitoba. In July 2006, Dr Nammi joined the Faculty of Pharmacy, University of Sydney as a SESQUI Research Fellow after having succeeded in the University of Sydney Postdoctoral Fellowship Programme.

Dr Nammi has worked in diversified research areas and published good number of research and review papers. So far, he published 33 publications to his credit in peer-reviewed Biomedical Journals. He is associated with several professional societies and is also a reviewer for Journals such as Journal of Pharmacology and Experimental Therapeutics, BMC Pharmacology, BMC Complementary and Alternative Medicine, Journal of Ethnopharmacology, Indian Journal of Pharmacology and Journal of Medical and Biological Sciences.

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Current Research Interests

  1. Pathophysiological mechanisms and therapeutic interventions involved in:

    Insulin resistance, obesity and type-2 diabetes.

    Beta-cell dysfunction and type-1 diabetes.

    Glucocorticoid excess and metabolic syndrome with special focus on 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1).

    Alcohol consumption (prenatal and postnatal): Development of diabetes and obesity.
  2. Evaluation of action mechanisms of traditional herbal medicines in the treatment of:

    Type 2 diabetes

    Obesity

    Metabolic syndrome
  3. Nuclear receptors (PPARs and LXRs) as potential drug targets in the treatment of metabolic disorders.
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Career Record

  • 1992-1996: B.Pharm, Faculty of Pharmaceutical Sciences, Andhra University, India.
  • 1996-1998: M.Pharm, Faculty of Pharmaceutical Sciences, Andhra University, India.
  • 1998-1999: Pharmacologist, Chemiloids Inc, India.
  • 1999-2003: PhD, Faculty of Pharmaceutical Sciences, Andhra University, India.
  • 2003-2004: Postdoctoral Fellow, Institute of Physiology, Eberhald Karl’s Universitate Tuebingen, Germany (DAAD Fellow).
  • 2005-2006: Postdoctoral Fellow, Section of Endocrinology & Metabolism, Department of Internal Medicine, University of Manitoba, Canada.
  • July 2006- todate: SESQUI Research Fellow, Herbal Medicines Research and Education Centre, Faculty of Pharmacy, University of Sydney, Australia.
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Research Publications

  • Srinivas Nammi, Korami Dembele, Nyomba BL. Increased 11β-hydroxysteroid dehydrogenase type-1 and hexose-6-phosphate dehydrogenase in liver and adipose tissue of rat offspring exposed to alcohol in utero. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2007; 292: R1101-R1109.
  • Rexhep Rexhepaj, Florian Grahammer, Harald Völkl, Christine Remy, Carsten A. Wagner, Diana Sandulache, Ferruh Artunc, Guido Henke, Srinivas Nammi, Giovambattista Capasso, Dario R. Alessi, Florian Lang. Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice. FASEB Journal 2006; 20: 2214-2222.
  • Koteswara Rao Nalamolu, Srinivas Nammi. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC Complementary and Alternative Medicine 2006; 6: 17.
  • Rajeswara Rao P, Nammi S, Routhu KV, Vijaya Raju AD. The antimicrobial activity of Heliotropium indicum Linn. in in vitro assay. Asia Pacific Journal of Pharmacology 2005; 16: 1-2.
  • Sandu C, Rexhepaj R, Grahammer F, McCormick JA, Henke G, Palmada M, Nammi S, Lang U, Metzger M, Just L, Skutella T, Dawson K, Wang J, Pearce D, Lang F. Decreased Intestinal Glucose Transport in the sgk3-knockout Mouse. Pfluger’s Archiv European Journal of Physiology 2005; 451: 437- 444.
  • Srinivas Nammi. Ayurveda and Diabetes. Physician’s Digest 2005; 14: 68-74. Invited review.
  • Srinivas Nammi, Krishna Murthy Boini, Sushruta Koppula, Satyanarayana Sreemantula. Reserpine-Induced Central Effects: Pharmacological Evidence for the Lack of Central Effects of Reserpine Methiodide. Canadian Journal of Physiology & Pharmacology 2005; 83: 509–515.
  • D. Sandulache, F. Grahammer, S. Nammi, F. Artunc, A. Mack, DY Huang, V. Vallon, P.Wulff, D. Kuhl, F.Lang. Renal Ca2+ handling in the sgk1 knockout mouse. Pfluger’s Archiv European Journal of Physiology 2005; 449: S99.
  • F. Artunc, F. Grahammer, D. Sandulache, C. Bohmer, M.Palmada, G. Henke, S. Nammi, A. Mack, D. Alessi, F. Lang. Impaired intestinal amino acid absorption in PDK1 deficient mice. Pfluger’s Archiv European Journal of Physiology 2005; 449: S65.
  • Sreemantula S, Boini KM, Koppula S, Kilari EK, Nammi S. Indirect Biochemical Evidence that Reserpine Methiodide Produces Selective Depletion of Peripheral Biogenic Amines in Rats. Die Pharmazie 2005; 60: 294–297.
  • Satyanarayana S, Nammi S, Kolanukonda R, Koppula S, Boini KM. Adaptogenic and Nootropic Activities of Vitis vinifera (Grape Seed) Extract: An Experimental Study in Rat Model. BMC Complementary and Alternative Medicine 2005; 5:1.
  • Rao K. Nalamolu, Krishna M. Boini, Srinivas Nammi. Effect of Chronic Administration of Boerhaavia diffusa Linn. Leaf Extract on Experimental Diabetes in Rats. Tropical Journal of Pharmaceutical Research 2004; 3: 305-309.
  • N. Koteswara Rao, MM. Annapurna, Boini KM, S. Nammi. Antidiabetic Activity of Boerhaavia diffusa L. Leaf Extract in Streptozotocin-Induced IDDM Model Rats. Asia Pacific Journal of Pharmacology 2004; 16: 67–70.
  • Satyanarayana Sreemantula, Krishna M. Boini, Srinivas Nammi. Reserpine Methonitrate, a Quaternary Analogue of Reserpine Augments Urinary Excretion of VMA and 5-HIAA without Affecting HVA in Rats. BMC Pharmacology 2004; 4: 30.
  • Satyanarayana S, Sushruta K, Sarma GS, Srinivas N, Subbaraju GV. Antioxidant Activities of Spicy Food Additives-Its Comparison with Ascorbic Acid in in vitro Systems. Journal of Herbal Pharmacotherapy 2004; 4(2): 1–10.
  • Srinivas Nammi, Krishna M. Boini, Eswar K. Kilari, Satyanarayana Sreemantula. Pharmacological Evidence for Lack of Central Effects of Reserpine Methonitrate: A Novel Quaternary Analog of Reserpine. Therapy 2004; 1(2): 231–239.
  • Krishna Murthy B, Annapurna A, Murali Krishna K, Rao RVK, Nammi S. Hypoglycemic and Antihyperglycemic Effects of a Polyherbal Formulation (RVF1) in Normal and Alloxan-Induced Diabetic Rats. Proceedings of AP Academy of Sciences 2004; 8: 211–214.
  • Christina Birka, Philipp A. Lang, Daniela S. Kempe, Lena Hoefling, Valerie Tanneur, Christoph Duranton, Srinivas Nammi, Guido Henke, Stephan M. Huber, Thomas Wieder, Florian Lang. Enhanced Susceptibility of Erythrocyte Apoptosis following Phosphate Depletion. Pfluger’s Archiv European Journal of Physiology 2004; 448: 471–477.
  • Srinivas Nammi, Saisudha K, Krishna M. Chinnala, Krishna M. Boini. Obesity: An overview on its current perspectives and treatment options. Nutrition Journal 2004; 3: 3.
  • Sudhakar M, Rao Ch V, Rao AL, Ramesh A, Srinivas N, Raju DB, Krishna Murthy B. Antinociceptive and anti-inflammatory effects of the standardized oil of Indian Callistemon tanceolatus leaves in experimental animals. East Central African Journal of Pharmaceutical Sciences 2004; 7: 1-7.
  • Krishna Murthy B, Nammi S, Kota MK, Koteswara Rao N, Krishna Rao RV Annapurna A. Evaluation of Hypoglycemic and Antihyperglycemic Effects of Datura metel (Linn.) Seeds in Normal and Alloxan-Induced Diabetic Rats. Journal of Ethnopharmacology 2004; 91: 95–98.
  • Satyanarayana S, Sarma GS, Ramesh A, Sushruta K, Srinivas N. Evaluation of Herbal Preparations for Hypoglycemic Activity in Normal and Diabetic Rabbits. Pharmaceutical Biology 2003; 41: 466–472.
  • Srinivas Nammi, Rambabu Gudavalli, Behara S Ravindra Babu, Durga S Lodagala, Krishna M Boini. Possibel Mechanisms of Hypotension produced by 70% Alcoholic Extract of Terminalia arjuna in Anaesthetized Dogs. BMC Complementary and Alternative Medicine 2003; 3: 5.
  • Srinivas Nammi, Murthy K Boini, Srinivas D Lodagala, Ravindra Babu S Behara. The Juice of Fresh Leaves of Catharanthus roseus Linn. Reduces Blood Glucose in Normal and Alloxan Diabetic Rabbits. BMC Complementary and Alternative Medicine 2003; 3: 4.
  • S. Nammi, SS. Ganti, DS. Lodagala, BSR. Babu. Hypoglycemic and Insulin Release Effects of Hugonia mystax in Rabbits. Asia Pacific Journal of Pharmacology 2003; 16: 1–3.
  • Rajeswara Rao P, Dora Babu M, Krishna Rao RV, Nammi S. Comparative Study of Sweet and Bitter Varieties of Aegle marmelos (L.) Correa for Hypoglycemic Activity in Rabbits. Journal of Natural Remedies 2002; 2: 88–91.
  • P. Rajeswara Rao, S. Nammi, Vijaya Raju AD. Studies on the Antimicrobial Activity of Heliotropium indicum. Journal of Natural Remedies 2002; 2: 195–198.
  • Annapurna A, Vijay Kumar K, Rambabu G, Krishna Kumar V, Nammi S. Ceramide: A Novel Second Messenger. Proceedings of Indian National Science Academy 2001; B67: 97–106.
  • Srinivas Nammi, Subramanya Sarma Ganti, Durga Srinivas Lodagala. Hypoglycemic Effect of Aegle marmelos Leaf Extract on Normal and Diabetic Model Rabbits. Asia Pacific Journal of Pharmacology 2001; 15: 9–11.
  • Srinivas Nammi, Durga Srinivas Lodagala. Ras Farnesyltransferase Inhibition: A Novel and Safe Approach for Cancer Chemotherapy. Acta Pharmacologica Sinica 2000; 21: 396–405.
  • S. Satyanarayana, N. Srinivas, NV. Subramanya Kumar. Studies on the Effect of 70% Alcoholic Extract of Terminalia arjuna on the Hematology of Dog. Indian Drugs 1999; 36: 198–199.
  • Subramanya Sarma Ganti, Srinivas Nammi, Durga Srinivas Lodagala.
    Molecular Mechanisms of Insulin Action. Proceedings of Indian National Science Academy 1999; 65(5): 245–256.
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