Yuhao Li
MD & PhD, Senior Research Fellow in Endocrinology & Metabolism
Qualifications
BMed MMed China PhD Japan
Contact Details
University of Sydney
Phone: +61 2 9351 8585
Fax: +61 2 9351 8638
Email:
Room S237
Pharmacy Building A15
The University of Sydney
NSW 2006 Australia
Research Interests
Pathophysiology, prevention and treatment of endocrine and metabolic disorders:
- Metabolic syndrome, diabetes, obesity, hypertension and their complications in the heart, kidneys and liver
- Ageing
- Gastrointestinal dysfunctions
- Chemotherapy-related side effects
- Management of chemotherapy-related side effects
- Modulators of peroxisome proliferator-activated receptors (PPARs), estrogen and androgen receptors (ER-alpha, ER-beta and AR), Atrium natriuretic peptide receptors (GC-A, GC-B), angiotensin II receptors (AT1, AT2), endothelin-1 receptors (ET-A and ET-B), nuclear factor (NF)-kappaB, serotonin receptors (5-HT1, 5-HT2) and dopamine receptors (DR1, DR2)
Track Record
1979-1996: Bachelor of Medicine, Master of Medicine, Associate Lecturer, Lecturer, Associate Professor, Supervisor of postgraduate students, the Head of Department of Pharmacology, Senior Physician (the first affiliated hospital), Guangzhou University of Traditional Chinese Medicine, China
1996-1999: Doctor of Philosophy (Pharmacology), Research Fellow, Kyoto Pharmaceutical University, Japan
1999-2002: Research Fellow in internal medicine, Kyoto University hospital, Japan
2002-: Senior Research Fellow in endocrinology and metabolism, Faculty of Pharmacy, The University of Sydney; Academic Consultant for development of natural products, Pharmafood Institute, Japan
Scientific Collaborators
- Kazuwa Nakao (MD & PhD, Professor) and Masaki Harada (MD & PhD, Director of Cardiology Group) (Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan)
- Johji Yamahara (PhD, Professor, Chair of The System for Enlightment of Natural Resources, Pharmafood Institute, Japan)
- Yoshihiko Saito (MD & PhD, Professor, First Department of Internal Medicine, Nara Medical University, Japan)
- Qinglin Yang (MD & PhD, Associate Professor, Director of Biochemistry Laboratory, Cardiovascular Research Institute, Morehouse School of Medicine, USA)
- Bing Zhang (MD & PhD, Professor, School of Chinese Medicine, Beijing University of Chinese Medicine, China)
- Chenchen Zhu (PhD, Professor, School of Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, China)
- Suping Wen (MD & PhD, Department of Health Science, University of Technology Sydney, Australia)
- Lan He (MD & PhD, School of Pharmaceutical Sciences, Sun Yat-Sen University, China)
Research Publications (1990 - 2009)
- Li Y*, Saito Y, Kuwahara K, Rong X, Kishimoto I, Harada M, Adachi Y, Nakanishi M, Kinoshita H, Horiuchi H, Murray M, Nakao K (2009). Natriuretic peptide receptor/guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart. Endocrinology (In press) (*the corresponding/senior author).
- Rong X, Li Y *, Ebihara K, Zhao M, Aini W, Kusakabe T, Hirata M, Miyamoto L, Nakao K (2009). The angiotensin II type 1 receptor blocker telmisartan rescues insulin resistance: an adipose tissue-independent pathway. Endocrinology (In press) (*the corresponding/senior author).
- Rong X, Peng G, Suzuki T, Yang Q, Yamahara J, Li Y* (2009) A 35-day gavage safety assessment of ginger in rats. Regulatory Toxicology and Pharmacology (In press) (*the corresponding/senior author)
- Xu KZY, Zhu C, Yamahara J, Li Y* (2009). Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity: upregulation of hepatic expression of genes responsible for fatty acid oxidation. Journal of Ethnopharmacology (In press) (*the corresponding/senior author).
- He L, Rong X, Jiang JM, Liu PQ, Li Y* (2008). Amelioration of anti-cancer agent adriamycin-induced nephrotic syndrome in rats by Wulingsan (Gorei-San), a blended traditional Chinese herbal medicine. Food and Chemical Toxicology 46:1452-60. (*the corresponding/senior author).
- Salam NK, Huang TH, Kota BP, Kim MS, Li Y, Hibbs DE (2008). Novel PPAR-gamma agonists identified from a natural product library: a virtual screening, induced-fit docking and biological assay study. Chemical Biology & Drug Design 71:57-70.
- Li Y*, Qi Y, Kim MS, Xu KZ, Huang THW, Rong X, Murray M, Yamahara J (2008). Increased renal collagen cross-linking and lipid accumulation in nephropathy of Zucker diabetic fatty rats. Diabetes/metabolism Research and Reviews 24:498-506. (*the corresponding/senior author).
- Rong X, Kim MS, Su N, Wen S, Matsuo Y, Yamahara J, Murray M, Li Y* (2008). An aqueous extract of Salacia oblonga root, a herb-derived peroxisome proliferator-activated receptor-alpha activator, by oral gavage over 28 days induces gender-dependent hepatic hypertrophy in rats. Food and Chemical Toxicology 46:2165-2172. (*the corresponding/senior author).
- Li Y*, Huang TH, Yamahara J (2008). Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity. Life Sciences 82:1045-1049. (*the corresponding/senior author).
- Huang TH, He L, Qin Q, Yang Q, Peng P, Harad M, Qi Y, Yamahara J, Roufogalis BD, Li Y* (2008). Salacia oblonga root decreases cardiac hypertrophy in Zucker diabetic fatty rats: inhibition of cardiac expression of angiotensin II type 1 receptor. Diabetes, Obesity & Metabolism 10:574-585. (*the corresponding/senior author).
- Li Y*, Qi Y, Huang TH., Yamahara J, Roufogalis BD (2008). Pomegranate flower: a unique traditional anti-diabetic medicine with dual PPAR-alpha/gamma activator properties (a review). Diabetes, Obesity & Metabolism 10:10-17. (*the corresponding/senior author)
- Yang Q, Li Y (2007). Roles of PPARs on regulating myocardial energy and lipid homeostasis. Journal of Molecular Medicine 85:697-706.
Huang TH, Tran VH, Roufogalis BD, Li Y (2007). Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells. Toxicology & Applied Pharmacology 218:30-36. (*the corresponding/senior author). - Huang TH, Tran VH, Roufogalis BD, Li Y (2007). Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells. European Journal of Pharmacology 565:158-165. (*the corresponding/senior author).
- Wen S, Huang TH, Li GQ, Yamahara J, Roufogalis BD, Li Y* (2006). Bromelain improves intestinal propulsive dysmotility of postoperative ileus in rats: inhibition of inducible nitric oxide synthase and nuclear factor-κB activation. Life Sciences 78:995-1002. (*the corresponding/senior author).
- Huang TH, Yang Q, Harada M, Uberai J, Radford J, Li GQ, Yamahara J, Roufogalis BD, Li Y* (2006). Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: Modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes. Toxicology and Applied Pharmacology 210:78-85. (*the corresponding/senior author)
- Huang TH, Peng P, Li GQ, Yamahara J, Roufogalis BD, Li Y*. (2006) Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: activation of PPAR-α. Toxicology & Applied Pharmacology 210:225-235. (*the corresponding/senior author).
- Huang TH, Li Y, Razmovski-Naumovski V, Tran VH, Li GQ, Duke CC, Roufogalis BD (2006). Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway. Journal of Biomedical Sciences 13:535-548
- Huang TH, Yang Q, Harada M, Li GQ, Yamahara J, Roufogalis BD, Li Y*. (2005) Pomegranate flower extract diminishes cardiac fibrosis in Zucker diabetic fatty rats: modulation of cardiac endothelin-1 and nuclear factor-kappaB pathways. Journal of Cardiovascular Pharmacology 46:856-862. (*the corresponding/senior author).
- Huang TH, Peng G, Kota BP, Li GQ, Yamahara J, Roufogalis BD, Li Y* (2005). Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: role of lowering circulating lipids. British Journal of Pharmacology 145:767-774. (*the corresponding/senior author).
- Li Y*, Wen S, Kota BP, Peng G, Li GQ, Yamahara J, Roufogalis BD (2005). Punica granatum flower extract, a potent α-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. Journal of Ethnopharmacology 99:239-244. (*the corresponding/senior author).
- Huang TH, Peng G, Kota BP., Li GQ, Yamahara J, Roufogalis BD, Li Y* (2005). Anti-diabetic action of Punica granatum flower extract: activation of PPAR-γ and identification of an active component. Toxicology & Applied Pharmacology 207:160-169. (*the corresponding/senior author).
- Wen S, Li Y (2005). Chinese medicine interactions (PART 2): Potential interactions with CNS, hormonal and immunomodulatory medication. Journal of Complementary Medicine 4 (4):107-111
- Wen S, Li Y (2005). Chinese medicine interactions (PART 1): potential interactions with concurrent ethical or OTC medication. Journal of Complementary Medicine 4 (3):105-110
- Li Y*, Peng P, GQ, Wen S, Roufogalis BD, Yamahara J (2004). Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese Zucker rats. Life Sciences 75:1735-1746. (*the corresponding/senior author).
- Li Y, Kishimoto K, Saito Y, Harada M, Kuwahara K, Izumi T, Hamanaka I, Takahashi N, Kawakami R, Tanimoto K, Nakagawa Y, Nakanishi M, Adachi Y, Garbers DL, Fukamizu A, Nakao K (2004). Androgen contributes to gender-related cardiac hypertrophy and fibrosis in mice lacking the gene encoding guanylyl cyclase-A. Endocrinology 145:951-958.
- Tom HW Huang, Bhavani P Kota, Li Y, Goh P, Roufogalis BD (2003). Clinical Review, Diabetes, “Ayurveda: Tapping into India’s rich anti-diabetic pharmacopoeia”. Pharmacy News 9-10.
- Li Y, Kishimoto I, Saito Y, Harada M, Kuwahara K, Izumi T, Takahashi N, Kawakami R, Tanimoto K, Nakagawa Y, Nakanishi M, Adachi Y, Garbers DL, Fukamizu A, Nakao K (2002). Guanylyl cyclase A inhibits angiotensin II type 1a receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart. Circulation 106:1722-1728.
- Kishimoto I, Saito Y, Li Y, Nakao K (2002). Cross-talk between the natriuretic peptide system and angiotensin system. Nippon Rinsho 60:1923-1928.
- Izumi T, Saito Y, Kishimoto I, Harada M, Kuwahara K, Hamanaka I, Takahashi N, Kawakami R, Li Y, Takemura G, Fujiwara H, Garbers DL, Mochizuki S, Nakao K (2001). Blockade of guanylyl cyclase A, a natriuretic peptide receptor, alleviates myocardial ischemia-reperfusion injury via inhibition of NF-B activation. Journal of Clinical Investigation 108:203-213.
- Matsuda H, Li Y, Yoshikawa M (2000). Possible involvement of 5-HT and 5HT2 receptors in acceleration of gastrointestinal transit by escins Ib in mice. Life Sciences 66:2233-2238.
- Matsuda H, Li Y, Yoshikawa M (2000). Possible involvement of dopamine and dopamine2 receptors in the inhibitions of gastric emptying by escins Ib in mice. Life Sciences 67:2921-2927.
- Li Y, Matsuda H, Wen S, Yamahara J, Yoshikawa M (2000). Enhancement by escins Ib and IIb of Mg2+ absorption from digestive tract in mice: role of nitric oxide. European Journal of Pharmacology 387:337-342.
- Li Y, Matsuda H, Yoshikawa M (2000). Acceleration of gastrointestinal transit by momordin Ic in mice: Possible involvement of 5-HT, 5-HT2 receptors and prostaglandins. European Journal of Pharmacology 392:71-77.
- Matsuda H, Li Y, Yoshikawa M (2000). Possible involvement of 5-HT, 5-HT2 receptors in acceleration of gastrointestinal transit by escins Ib in mice. Life Sciences. 66:2233-2238.
- Matsuda H, Li Y, Yoshikawa M (2000). Roles of endogenous prostaglandins and nitric oxide in inhibitions of gastric emptying and accelerations of gastrointestinal transit by escins Ia, Ib, IIa and IIb in mice. Life Sciences. 66:PL 41-46.
- Li Y, Matsuda H, Wen S, Yamahara J, Yoshikawa:M (1999) Structure-related enhancing activity of escins Ia, Ib, IIa, and IIb on Magnesium absorption in mice. Bioorganic & Medicinal Chemistry Letters 9:2473-2478.
- Matsuda H, Li Y, Yoshikawa M (1999). Effects of escins Ia, Ib, IIa, and IIb from horse chestnuts on gastrointestinal transit and ileus in mice. Bioorganic & Medicinal Chemistry 7:1737-1741.
- Matsuda H, Li Y, Yoshikawa:M (1999). Gastroprotection of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats. European Journal of Pharmacology 373:63-70.
- Li Y, Matsuda H, Yoshikawa M (1999). Effects of oleanolic acid glycosides on gastrointestinal transit and ileus in mice. Bioorganic Medicinal Chemistry 7:1201-1205.
- Matsuda H, Li Y, Yoshikawa M (1999). Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sciences 65:PL 27-32.
- Matsuda H, Li Y, Yamahara J, Yoshikawa M (1999). Inhibition of gastric emptying by triterpene saponin, momordin Ic, in mice: roles of blood glucose, capsaicin-sensitive sensory nerves and central nervous system. Journal of Pharmacological and Experimental Therapeutics 289:729-734.
- Yoshikawa M, Murakami T, Li Y, Shimada H, Yamahara J, Matsuda H (1999). Bioactive triterpene glycosides from several medicinal foodstuffs, in: Advances in Plant Glycosides, Chemistry and Biology. Chong-Ren Yang and Osamu Tanaka (Eds), 19-35, Elsevier, Amsterdam-Tokyo.
- Matsuda H, Li Y, Murakami M, Yamahara J, Yoshikawa M (1999). Effects of escins Ia, Ib, IIa, and IIb from horse chestnuts on gastric emptying in mice. European Journal of. Pharmacology 368:237-243.
- Matsuda H, Li Y, Murakami T, Yamahara J, Yoshikawa (1999). Structure-related inhibitory activity of oleanolic acid glycosides on gastric emptying in mice. Bioorganic Medicinal Chemistry 7:323-327.
- Matsuda H, Li Y, Murakami T, Yamahara J, Yoshikawa M (1998). Protective effects of oleanolic acid oligoglycosides on ethanol- or indomethacin-induced gastric mucosal lesions in rats. Life Sciences 63:PL 245-250.
- Matsuda H, Murakami T, Li Y, Yamahara Y, Yoshikawa M (1998). Mode of action of escins Ia and IIa and E,Z-senegin II on glucose absorption in gastrointestinal tract. Bioorganic & Medicinal Chemistry 6:1019-1023.
- Matsuda H, Li Y, Murakami T, Matsumura N, Yamahara J, Yoshikawa M (1998). Antidiabetic principles of natural medicines. III. Structure-related inhibitory activity and action mode of oleanolic acid glycosides on hypoglycemic activity. Chemical & Pharmaceutical Bulletin 46:1399-1403.
- Yoshikawa Y, Shimada H, Nishida N, Li Y, Toguchida I, Yamahara J, Matsuda H (1998). Antidiabetic principles of natural medicines. II. aldose reductase and -glucosidase inhibitors from Brazilian natural medicine, the leaves of Myrcia multiflora DC. (Myrtaceae): structures of myrciacitrins I and II and myrciaphenones A and B. Chemical & Pharmaceutical Bulletin 46:113-119.
- Matsuda H, Li Y, Murakami T, Ninomia K, Araki N, Yoshikawa M, Yamahara J (1997). Antiinflammatory effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L. Bioorganic & Medicinal Chemistry Letters 7:1611-1616.
- Matsuda H, Li Y, Murakami T, Ninomiya K, Yamahara J, Yoshikawa M (1997). Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biological & Pharmaceutical Bulletin 20:1092-1095.
- Yoshikawa M, Murakami T, Kadoya K, Li Y, Murakami N, Yamahara J, Matsuda H (1997). Medicinal foodstuffs. IX. The inhibitors of glucose absortion from the leaves of Gymnema sylvestre R. BR. (Asclepiadaceae): Strutures of gymnemosides a and b. Chemical & Pharmaceutical Bulletin 45:1671-1676.
- Wu Q, Li Y, Liang M, Han J, Huang M, Zhou G (1996). Experimental studies of Nujin Pill on estrogenoid effect. Chinese Journal of Experimental Traditional Medical Formulae, 2:28-31.
- Wu Q, Li Y, Liang S, Chen S, Han J, Cheng J (1996). Effect of Nujin Pill on pituitarium-ovary axis in rats. Chinese Journal of Experimental Traditional Medical Formulae 2:14-17.
- Wu Q, Li Y, Han J, Zheng Q (1995). Pharmacological studies of Hua Di Shao Shang Gao. Journal of New Chinese Medicine. 27:58-59.
- Li Y*, Wu Q, Wen S, Han J, Liang S (1994). Effect of Luo Tong Pian on injury of sciatic nerve in rats. New Chinese Drug and Clinical Pharmacology 5:31-33. (*the corresponding/senior author).
- Li Y*, Deng X, Wu Q, Han J, Liang S (1994). Effects of Wu Zi Yan Zong Wan on lipid metabolism and liver pathological changes in ethanol-induced liver injury rats. Journal of Chinese Materia Medica19:300-302. (*the corresponding/senior author).
- Li Y*, Wu Q, Han J, Liang S (1993). Pharmacological studies of Vernoniae cinereae. Journal of Chinese Medicinal Materials 16:31-33. (*the corresponding/senior author).
- Li Y*, Wu Q, Han J, Liang M (1993). Effects of Wu Zi Yan Zong Wan on immune function in mice. Journal of Guangzhou University of Traditional Chinese Medicine 10:220-223. (*the corresponding/senior author).
- Li Y*, Wu Q, Han J, Zhao W, Liang S (1993). Effects of Wu Zi Yan Zong Wan on diabetes induced by cyproheptadine in rats. Journal of Guangzhou University of Traditional Chinese Medicine 10:87-91. (*the corresponding/senior author).
- Li Y*, Wu Q, Han J, Huang J, Xie S, Liang S (1993). Studies of Shu Fu Bao on therapeutic effects and toxicity. Journal of Guangzhou University of Traditional Chinese Medicine 10:150-154. (*the corresponding/senior author).
- Wu Q, Li Y, Han J, Zhao M (1993). Songming Liang. Pharmacological studies of Xiao Ke Wan (pill for diabetes). Journal of New Chinese Medicine 25:51-53.
- Li Y*, Wu Q, Li R, Han J, Liang S (1992). Antipyretic and anti-inflammatory effects of Basellae rubrae in animals. Journal of Chinese Medicinal Material 15:32-35. (*the corresponding/senior author).
- Li Y*, Wu Q, Li R, Han J, Liang S (1992). Pharmacological studies of Wu Zi Yan Zong Wan: I. Effects on functions of reproductive system in animals. Journal of Pharmacology and Clinic of Chinese Materia Medica 8:4-6. (*the corresponding/senior author).
- Li Y*, Wu Q, Cheng S, Han J, Liang S (1992). Pharmacological studies of Wu Zi Yan Zong Wan: II. Effects on normal serum glucose and alloxan-induced diabetes in mice. Journal of Pharmacology and Clinic of Chinese Materia Medica 8:10-12. (*the corresponding/senior author).
- Cheng S, Li Y, Wu Q, Han J, Liang S (1992). Effects of Wu Zi Yan Zong Wan on diabetes induced by streptozotocin in Rats. Journal of New Chinese Medicine 24:52-56.
Li Y*, Wu Q, Han J, Liang Q, Liu Z, Liang S (1992). Effects of Wu Zi Yan Zong Wan on glucose tolerance and perioxidate lipid in blood and liver in ethanol-induced liver injury rats. Journal of Guangzuou University of Traditional Chinese Medicine 9:143-146. (*the corresponding/senior author). - Li Y*, Yamahara J, Liang S (1992). Pharmacological studies of Sophorae flavescens for tonifying stomach. Journal of Guangzuou University of Traditional Chinese Medicine 9:83-85. (*the corresponding/senior author).
- Matsuda H, Li Y, Tanikuchi K, Yamahara j, Tamai Y. Imaging analysis of antiulcer action and the active constituent of Atractylodes Rhizoma. YAKUGAKU ZASSHI 111:36-39.
- Li Y*, Zhang Z, Liang S (1991). Studies of Luo De Shu on Mechanism of antiinflammation. Journal of Guangzhou University of Traditional Chinese Medicine 8:285-288. (*the corresponding/senior author).
- Li Y*, Tanikuchi K, Yamahara J (1991). Effect of Atractylodes lancea Rhizoma on anoxia in mice and its active constituents. Journal of Chinese Medicinal Material 14:41-43. (*the corresponding/senior author).
- Li Y*, Tanikuchi K, Yamahara J (1991). Effects of Atractylodes macrocephalae Rhizoma on gastrointestinal functions in animals. Journal of Chinese Medicinal Material 14:38-40. (*the corresponding/senior author).
- Li Y*, Wu Q, Li R, Han J, Zhao W, Liang S, Cheng S (1991). Effects of Sheng-jing Capsule on functions of male reproductive system in animals. New Chinese Drug and Clinical Pharmacology 2:41-44. (*the corresponding/senior author).
- Wu Q, Li Y, Han J, Liang S, Cheng S (1991). Pharmacological studies of Suo Quan Wan. Journal of New Chinese Medicine 23:49-50.
Wu Q, Li Y, Han J, Liang S, Jian Z (1991). Screening studies of Chinese recipes used for diabetes. Journal of Guangzhou University of Traditional Chinese Medicine 8:219-223. - Matsuda H, Li Y, Taniguchi K, Yamahar J, Tamai Y (1991). Imaging analysis of antiulceration and the active constituent of Atractilodi rizomi. Yakugaku Zasshi. 111:36-39.
- Yamahara J, Matsuda H, Huang Q, Li Y, Fujimura H (1990). Intestinal motility enhancing effect of Atractylodes lancea rhizome. Journal of Ethnopharmacology 29:341-344.
- Yamahara J, Huang Q, Li Y, Xu L, Fujimura H (1990). Gastrointestinal motility enhancing effect of ginger and its active constituents. Chemical & Pharmaceutical Bulletin 38:430-431.
- Yamahara J, Li Y, Tamai Y (1990). Anti-ulcer effect in rats of bitter cardamon constituents. Chemical & Pharmaceutical Bulletin 38:3053-3054.
- Li Y*, Zhang G, Liang S (1990). Studies of Luo De Shu on inflammation in animals. Journal of Guangzhou University of Traditional Chinese Medicine 7:232-235. (*the corresponding/senior author).
