Andy Lee

B.Sci, M.Sci (Research)

Contact Details

Room: Medical Foundation Building
Telephone: +61 2 9036 3261
Email:

Degree: Doctor of Philosophy
Supervisor: Professor Michael Murray
Associate Supervisor: Dr Graham Robertson (Concord Hospital and WMI)

Areas of Research Interest: Molecular Biology, Transcription factors, Transgenic mice

Potential bZip Transcription Factors that Regulate the Gene Expression of a Special P450 Gene, CYP2J2

CYP2J2 is a P450 gene that’s not only involved in drug and lipid metabolism but also in carcinogenesis. The fatty acids derived from the enzyme encoded by this gene have been shown to have signalling effects in these events. Literally, if we can control the CYP2J2 expression, we will be able to increase more of the beneficial fatty acids to help stressed cells in ischaemia (eg. stroke or atherosclerosis) or even to control cancer cell proliferation. I have taken biochemical and molecular approaches to unravel certain bZip transcription factors that play critical roles in the signalling pathways, which hopefully will help us design new pharmacological strategies.