Michelle Ng

Graduated Diploma in Pharmaceutical Science

Contact Details

Room: Room N217
Telephone: +61 2 9351 3808
Email:

Degree: Doctor of Philosophy
Supervisor: Dr. Colin Duke
Associate Supervisor: Dr. Van Tran

Areas of Research Interest: Synthesis of natural and synthetic oxidized lipids and investigation of their anticancer and other biological activities.

Bioactive oxylipins derived from the omega-3 essential fatty acid alpha-linolenic acid.

Naturally occurring oxylipins, known as oxidized polyenoic fatty acid, have important roles in animals and plants for cell signaling and defense in response to attack from microbes or pathogens. They exhibited cytotoxicity against a panel of human cancer cells including lung cancer cell A549a and human erythroleukemia K562b. It has been reported recently that a wide range of small oxylipin molecules with conjugated double bond and allylic alcohol (-OH) showed activity against cancer cellsc. However, biological studies of natural or bio-synthetic oxylipins have been very sparse due to limited availability of the compounds, my study therefore aims to chemically synthesize oxylipins mainly the mono-OH allylic derivatives with conjugated double bond from omega-3 essential fatty acid to investigate their anticancer activity/toxicity.