Research by other Faculty members
Dr Colin Duke
- Boux, L.J.; Duke, C.C.; Holder, G.M.; Ireland, C.M. and Ryan, A.J. (1983).
Metabolism of 7-methylbenz[c]acridine : comparison of rat liver and lung microsomal preparations and identification of some minor metabolites.
Carcinogenesis, 4(11), 1429-1435. - Duke, Colin C.; Murphy, Peter T. and Holder, Gerald M. (1984).
Synthesis of the non-K-region dihydrodiols of 7-methylbenz[c]acridine.
J. Org. Chem., 49, 4446-4451. - Gill, Jennifer H.; Duke, Colin C.; Rosario, Christopher A.; Ryan, Adrian J. and Holder, Gerald M. (1986).
Dibenz[a,j]acridine metabolism : identification of in vitro products formed by liver microsomes from 3-methylcholanthrene pretreated rats.
Carcinogenesis, 7(8), 1371-1378. - Gill, J.H.; Bonin, A.M.; Podobna, E.; Baker, R.S.U.; Duke, C.C.; Rosario, C.A.;
Ryan, A.J. and Holder, G.M. (1986).
7-Methylbenz[c]acridine : mutagenicity of some of its metabolites and derivatives, and the identification of trans-7-methylbenz[c]acridine-3,4-dihydrodiol as a microsomal metabolite.
Carcinogenesis, 7(1), 23-31. - Chang,Richard L.; Levin, Wayne; Wood, Alexander W.; Shirai, Naohiro; Ryan, Aarian, J.; Duke, Colin C.; Jerina, Donald M.; Holder, Gerald M. and Conney, Allan H. (1986). High tumorigenicity of the 3,4-dihydrodiol of 7-methylbenz[c]acridine on mouse skin and in newborn mice.
Cancer Res., 46(9), 4552-4555. - Rosario, Christopher A.; Holder, Gerald M. and Duke, Colin C. (1987). Synthesis of potential metabolites of dibenz[a,j]acridine : Dihydrodiols and phenols.
J. Org. Chem., 52(6), 1064-1072. - Rosario, Christopher A.; Duke, Colin C.; Gill, Jennifer H.; Dawson, Michael;
Holder, Gerald, M.; Ghazy, Tahany and Long, Mervyn A. (1987). The preparation of regiospecific tritiated and deuterated dibenzacridines by catalytic exchange and [14-14C]-dibenz[a,j]acridine.
J. Labelled Compd. Radiopharm., 24(1), 23-28. - Duke, Colin C. and Wells, Robert J. (1987). Investigation of readily available chiral compounds for preparative scale resolutions.
Aust. J. Chem., 40(10), 1641-1654. - Gill, Jennifer H.; Duke, Colin C.; Ryan, Adrian J. and Holder, Gerald M. (1987).
Dibenz[a,j]acridine : distribution of metabolites formed by liver and lung microsomes from control and pretreated rats.
Carcinogenesis, 8(3), 425-431. - Duke, Colin C. and Holder, Gerald M. (1988). endo-1,4,5,6,7,7-Hexachlorobicyclo[2.2.1]
hept-5-ene-2-carboxylic acid, a superior resolving agent for separation of enantiomers of hydroxylated derivatives of two azaaromatic hydrocarbons.
J. Chromatogr., 430(1), 53-64. - Duke, C.C.; Holder, G.M.; Rosario, C.A. and Ryan, A.J. (1988).
Stereochemistry of the major rodent liver microsomal metabolites of the Carcinogen, Dibenz[a,j]acridine.
Chem. Res. Toxicol., 1, 294-303. - Bonin, Antonio M.; Rosario, Christopher A.; Duke, Colin C.; Baker, Robert S.U.;
Ryan, Adrian J. and Holder, Gerald M. (1989).
The mutagenicity of dibenz[a,j]acridine, some metabolites and other derivatives in bacteria and mammalian cells.
Carcinogenesis, 10(6), 1079-1084. - Robinson, H.K.; Duke, C.C.; Holder, G.M. and Ryan, A.J. (1990).
The metabolism of the carcinogen dibenz[a,j]acridine in isolated rat hepatocytes and in vivo in rats.
Xenobiotica, 20(5), 457-70. - Fraser, Joan V., Duke, Colin C.; Holder, Gerald, M. and Moore, Douglas E. (1990).
Solvolysis of the bay-region diol epoxides of 7-methylbenz[c]acridine in aqueous solution and the effect of DNA. Chem. Res. Toxicol., 3(2), 125-132. - Moore, Douglas E.; Roberts Thomson, Sarah; Zhen, Dong and Duke, Colin C. (1990). Photochemical studies on the anti-inflammatory drug diclofenac.
Photochem. Photobiol., 52(4), 685-90. - Sayer, Jane M.; Lehr, R.E., Kumar S.; Yagi, H.; Yeh, H.J.C.; Holder, G.M.,
Duke C.C., Silverton, J.V.; Gibson, C. and Jerina, D.M. (1990).
Comparative solvolytic reactivity of bay-region diol epoxides derived from dibenz[a,j] anthracene and dibenzacridines.
J. Am. Chem. Soc., 112(3), 1177-1185. - Duke, Colin C.; Hambley, Trevor W.; Holder, Gerald M.; Navascues, Corina O.;
Roberts Thomson Sarah and Ye, Yuerong. (1991). The stereochemistry of the major rat liver microsomal metabolites of the carcinogen 7-methylbenz[c]acridine.
Chem. Res. Toxicol., 4(5), 546-555. - Carter, Stephen R., Duke, Colin C., Cutler, David. J. and Holder, Gerald M. (1992).
Sensitive stereospecific assay of warfarin in plasma: Reversed phase high performance liquid chromatographic separation using diastereoisomeric esters of(1S,2S,4R)-endo-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]-hept-5-ene-2-carboxylic acid. J. Chromatogr., 574(1), 77-83. - Ye, Yuerong, Holder, Gerald M. and Duke, Colin C. (1993).
The preparation of 2H and 3H-labelled 7,9- and 7,10-dimethylbenz[c]acridine by catalytic dehalogenation.
J. Labelled Compounds and Radiopharm. 33, 1-10. - Scharping, C.E.; Duke, C.C.; Holder, G.M. and Larden, D. (1993).
The hepatic metabolism of two methyl quinolines.
Carcinogenesis, 14(5), 1041-1047. - Duke, Colin C.; Carter, Stephen R.; Hambley, Trevor W.; Holder, Gerald M. and Cutler, David J. (1994).
Analysis of warfarin enantiomers: Chromatographic separation of six stereoisomeric esters prepared from (-)-(1S,2R,4R)-endo-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2-carboxylic acid.
Chirality, 6(8), 670-680. - Grech, Josef N.; Li, Qian; Roufogalis, Basil D. and Duke, Colin C. (1994).
Novel Ca2+-ATPase inhibitors from the dried root tuber of Polygonum multiflorum.
J. Nat. Prod., 57, 1682-1687. - Ye, Yuerong, Duke, Colin C. and Holder, Gerald M. (1995). Identification of hepatic metabolites of two highly carcinogenic polycyclic aza-aromatic compounds, 7,9-dimethylbenz[c]acridine and 7,10-dimethylbenz[c]acridine.
Chem. Res. Toxicol., 8(2), 188-202. - Ye, Yuerong, Duke, Colin C. and Holder, Gerald M. (1995).
The stereochemistry of major rat hepatic metabolites of 7,9-dimethylbenz[c]acridine and 7,10-dimethylbenz[c]acridine.
Chem. Res. Toxicol., 8, 203-208. - Duke, Rujee K., Allan, Robin D., Johnston Graham A.R.; Mewett, Kenneth N., Mitrovic, Ann D, Duke, Colin C. and Hambley, Trevor W. (1995). Idiospermuline, a trimeric pyrrolidinoindoline alkaloid from the seed of Idiospermum australiense.
J. Nat. Prod., 58, 1200-1208. - Huang, Jui Li, Mather, Laurence E. and Duke, Colin C. (1995). High-performance liquid chromatographic determination of thiopentone enantiomers in sheep plasma.
J. Chromatogr. B, 673, 245-250. - Roberts-Thomson, Sarah J.; McManus, Michael E.; Duke, Colin C., Agnew, Robyn and Holder, Gerald M. (1996). Stereoselective and regioselective hydration of 7-methylbenz[c]acridine-5,6-oxide enantiomers by rodent and human microsomal epoxide hydrolases.
Mol. Pharmacol., 49(1), 105-111. (5.678) - Tran Van H; Roufogalis, Basil D. and Duke Colin C. (1997).
An efficient synthesis of 5,5�-(tetradecane-1,14-diyl)bis(1,3-dihydroxy-2-methylbenzene) and related substances.
Aust. J. Chem., 50(7), 747-750. - Roufogalis, Basil D.; Li, Qian; Tran, Van H.; Kable, Eleanor P.W. and Duke, Colin C. (1999). Investigation of plant-derived phenolic compounds as plasma membrane Ca2+-ATPase inhibitors with potential cardiovascular activity. Drug Dev. Res., 46 (3/4), 235-249.
- Mather, Laurence E.; Edwards, Stephen R.; Duke, Colin C. and Cousins, Michael J. (1999). Enantioselectivity of thiopental distribution into the central neural tissue of rats: an interaction with halothane.
Anesth. Analg. (Baltimore), 89(1), 230-235. - Mather, Laurence E.; Edwards, Stephen R.; Duke, Colin C. (1999).
Electroencephalographic effects of thiopentone and its enantiomers in the rat: correlation with drug tissue distribution.
Br. J. Pharmacol. 128(1), 83-91. - Mather, Laurence E.; Edwards, Stephen R. and Duke, Colin C. (1999). Electroencephalographic effects of thiopentone and its enantiomers in the rat.
Life Sci. 66(2), 105-114. - Mather, L. E., Edwards, S. R., Duke, C. C. and Cousins, M.J. (2000).
Microdialysis study of the blood-brain equilibration of thiopental enantiomers.
Br. J. Anaesth. 84(1), 67-73. - Tjendraputra, Effie; Tran, Van H.; Liu-Brennan, Damien; Roufogalis, Basil D. and Duke, Colin C. (2001). Effects of ginger constituents and synthetic analogues on cyclooxygenase-2 (COX-2) enzyme in intact cells.
Bioorg. Chem. 29(3), 156-163. - Koo, L. K. K, Ammit, A.J.; Tran, V. H.; Duke, C. C. and Roufogalis, B. D. (2001).
Gingerols and Related Analogues Inhibit Arachidonic Acid-Induced Human Platelet
Serotonin Release and Aggregation.
Thrombosis Research, 103(5), 387-397. - Bhattarai, Sushila., Tran; Van Hoan and Duke, Colin Charles (2001). The stability of gingerol and shogaol in aqueous solutions. J. Pharm. Sci., 90(10), 1658-1664.
- Dedov, VN, Tran, VH, Duke, CC, Connor, M, Christie, MJ, Mandadi, S and Roufogalis, BD (2002) Gingerols: a novel class of vanilloid receptor (VR1) agonists.
Br. J. Pharmacol., (2002), 137(6), 793-798. - Chebib (Collins) M, Duke RK, Duke CC, Connor M, Mewett KN, Johnston GAR. (2003). Convulsant actions of calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
- Nurtjahja-Tjendraputra, E., Ammit, A.J., Roufogalis, B.D., Tran, V.H. & Duke, C.C. (2003). Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger Thrombosis Research, 111, 259-265.
- Coxeter, P. D.; McLachlan, A. J.; Duke, C. C.; Roufogalis, B. D. (2004). Herb-drug interactions: An evidence based approach. Current Medicinal Chemistry 11(11), 1513-1525.
- Mather, L. E.; Duke, C. C.; Ladd, L. A.; Copeland, S. E.; Gallagher, G.; Chang, D. H. T. (2004). Direct Cardiac Effects of Coronary Site-directed Thiopental and Its Enantiomers: A Comparison to Propofol in Conscious Sheep. Anesthesiology 101(2), 354-364.
- Jiang X; Williams K M; Liauw W S; Ammit A J; Roufogalis B D; Duke C C; Day R O; McLachlan A J (2004). Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. British Journal of Clinical Pharmacology 57(5), 592-599. [Erratum in: Br J Clin Pharmacol. 2004 Jul;58(1):102]
- Jiang X, Williams KM, Liauw W, Ammit AJ, Roufogalis BD, Duke CC, Day RO, McLachlan AJ. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 59(4), 425-432
- Jiang X, Williams KM, Liauw W, Ammit AJ, Roufogalis BD, Duke CC, Day RO, McLachlan AJ. (2005) Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 59(4), 425-432.
- Razmovski-Naumovski V, Duke RK, Turner P, Duke CC (2005) (20S)-2α,3β,12β-Trihydroxydammar-24-ene 20-O-β-D-glucopyranoside (Gynosaponin TN1) as the 2.5-methanol solvate. Acta Crystallographica, E61(5), O1239-O1241.
- Huang THW, Razmovski-Naumovski V, Salam NK, Duke RK, Tran VH, Duke CC, Roufogalis BD (2005) A novel LXR-α activator identified from the natural product Gynostemma pentaphyllum. Biochem. Pharmacol., 70(9), 1298-1308.
- Razmovski-Naumovski V, Huang THW, Tran VH, Li GQ, Duke CC, Roufogalis BD (2005) Chemistry and pharmacology of Gynostemma pentaphyllum. Phytochem Rev, 4, 197–219.
- Huang THW, Tran VH, Duke RK, Tan S, Chrubasik S, Roufogalis BD, Duke CC (2006) Harpagoside suppresses lipopolysacharride-induced iNOS and COX-2 expression through inhibition of NF-κB activation. Journal of Ethnopharmacology 104, 149-155.
- Razmovski-Naumovski V, Li GQ, Duke CC (2005) Gynostemma pentaphyllum cultivation in Sydney, Australia and its comparison with products from China. Journal of Applied Horticulture 7(2), 99-104.
- Lee, Ju-young; Duke, Rujee K.; Tran, Van H.; Hook, James M.; Duke, Colin C.(2006). Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry, 67(23), 2550-2560.
- Huang, Tom Hsun-Wei; Li, Yuhao; Razmovski-Naumovski, Valentina; Tran, Van Hoan; Li, George Qian; Duke, Colin C.; Roufogalis, Basil D. (2006). Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway. Journal of Biomedical Science, 13(4), 535-548.
- Tran, Van H.; Kantharaj, Ravi; Roufogalis, Basil D.; Duke, Colin C. (2006).An efficient and facile synthesis of capsaicin-like compounds as agonists of the TRPV1 receptor. European Journal of Organic Chemistry, (13), 2970-2976.
- Hesse C, Razmovski-Naumovski V, Duke CC, Davies NM, Roufogalis BD (2007). Phytopreventative effects of Gynostemma pentaphyllum against acute indomethacin-induced gastrointestinal and renal toxicity in rats. Phytother. Res. 21(6), 523-530.
- Bhattarai S, Tran VH, Duke CC (2007). Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids. Journal of Pharmaceutical and Biomedical Analysis 45, 648-653.
- Cui PH, Duke RK, Duke CC (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. Chemistry and Physics of Lipids 152(2), 122-130.
- Cui PH, Duke RK, Tattam BN, Duke CC (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 2: Mass spectral characterization. Chemistry and Physics of Lipids 152(2), 65-70.
- Fu S, Tattam BN, Duke CC, Ramzan I (2009). High performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites. Biomedical Chromatography 23(1), 81-91.
- Li Z, Tran VH, Duke RK, Ng MCH, Yang D and Duke CC (2009) Synthesis and biological activity of hydroxylated derivatives of linoleic acid and conjugated linoleic acids. Chemistry and Physics of Lipids 158, 39-45.
- Cui PH, Zhang WV, Hook JM, Tattam BN, Duke CC and Murray M (2009) Synthesis and NMR characterization of the methyl esters of eicosapentaenoic acid monoepoxides. Chemistry and Physics of Lipids 159, 30-37.
- BOOK CHAPTER
Razmovski-Naumovski V, Duke RK, Tran VH, Li GQ Tattam BN, Roufogalis BD and Duke CC. Current Methods in the isolation and characterization of saponins from Gynostemma pentaphyllum. Current Trends in Phytochemistry, Chapter 10, pages 283-309 ISBN: 978-81-308-0277-0 Editor: Francesco Epifano, Research Signpost 2008.
Professor Michael Murray
- Synthesis and NMR characterization of methyl esters of eicosapentanenoic acid monoepoxides. Pei H. Cui, Wei V Zhang,James Hook, Bruce N Tattam, Colin C. Duke, Michael Murray.Chemistry and Physics of Lipids 159 (2009) 30-37
- A high-throughput liquid chromatography/tandem mass spectrometry for simultaneous in vivo phenotyping of five major cytochrome P450 enzymes in patients. Ghassabian Sussan, Chetty Manoranjenni, Tattam Bruce N, Glen John, Rahme Jeannie, Stankovic Zvijezdana, Iqbal Ramzan, Murray Michael, & McLachlan, Andrew. Therapeutic Drug Monitoring: Volume 31(2) April 2009 pp239-246
- A High throughput assay for Irinotecan(CTP-11) and its two major metabolites using liquid chromatography/tandem mass spectrometry. D’Esposito Fabrizio, Tattam Bruce N, Ramzan Iqbal, Murray Michael. Journal of Chromatography B, 875 (2008) 522-530
Professor Andrew McLachlan
- A high-throughput liquid chromatography/tandem mass spectrometry for simultaneous in vivo phenotyping of five major cytochrome P450 enzymes in patients. Ghassabian Sussan, Chetty Manoranjenni, Tattam Bruce N, Glen John, Rahme Jeannie, Stankovic Zvijezdana, Iqbal Ramzan, Murray Michael, & McLachlan, Andrew. Therapeutic Drug Monitoring: Volume 31(2) April 2009 pp239-246
- Plasma Distribution and its Impact on Pharmacokinetics Liposomal Amphotericin B in Paediatric Patients with Malignant Diseases. Ying Hong,1 Peter J. Shaw,2 Bruce N. Tattam,1 Christa E. Nath,3 John W. Earl,3 and Andrew J. McLachlan1* . European Journal of Clinical Pharmacology . Feb (2007) 63: 165-172
- In Vitro Distribution and Protein Binding of Tacrolimus In Human Blood. H.Zahir, RA Nand, KF Brown, BN Tattam & AJ McLachlan Journal of Pharmacological and Toxicological Methods Volume 46, Issue 1, pp.27-35 [Abstract]
Professor Iqbal Ramzan
- High performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites Shuang Fu, Bruce N. Tattam, Colin C. Duke, Iqbal Ramzan Biomedical Chromatogr, 2009; Jan 23:81-91
- A high-throughput liquid chromatography/tandem mass spectrometry for simultaneous in vivo phenotyping of five major cytochrome P450 enzymes in patients. Ghassabian Sussan, Chetty Manoranjenni, Tattam Bruce N, Glen John, Rahme Jeannie, Stankovic Zvijezdana, Iqbal Ramzan, Murray Michael, & McLachlan, Andrew. Therapeutic Drug Monitoring: Volume 31(2) April 2009 pp239-246
- A High throughput assay for Irinotecan(CTP-11) and its two major metabolites using liquid chromatography/tandem mass spectrometry. D’Esposito Fabrizio, Tattam Bruce N, Ramzan Iqbal, Murray Michael. Journal of Chromatography B, 875 (2008) 522-530
Past Members Of Staff
Assoc Prof Douglas E Moore
- Tamat, S.R, and Moore, D.E
Photolytic decomposition of hydrochlorothiazide.
J. Pharm. Sci., 72, 180-183, 1983. - Moore, D.E., and Sithipitaks, V.
Photolytic degradation of frusemide.
J. Pharm. Pharmacol., 35, 489-493, 1983. - Hemmens, V.J., and Moore, D.E.
Photo-oxidation of 6-mercaptopurine in aqueous solution.
J. Chem. Soc. Perkin Trans. II, 209-211, 1984. - Hemmens, V.J., and Moore, D.E.
Photochemical sensitization by azathioprine and its metabolites. I.6-Mercaptopurine.
Photochem. Photobiol., 43, 247-255, 1986. - Hemmens, V.J., and Moore, D.E.
Photochemical sensitization by azathioprine and its metabolites. II.
Azathioprine and nitroimidazole metabolites.
Photochem. Photobiol., 43, 257-262, 1986. - Burt, C.D., Cheung, H.T.A., Holder, G.M., and Moore, D.E.
Photooxidation of 7-methylbenz[c]acridine in methanol - identification of two primary photoproducts. J. Chem. Soc. Perkin Trans. I., 741-745, 1986. - Wilkins, B.J., Gainsford, G.J., and Moore, D.E.
Photolytic rearrangement of metronidazole to a 1,2,4-oxadiazole.
Crystal structure of its 4-nitrobenzoate derivative.
J. Chem. Soc. Perkin Trans. I, 1987, 1817-1820. - Moore, D.E.
Principles and practice of drug photodegradation studies.
J. Pharm. Biomed. Anal., 5, 441-455, 1987. - Moore, D.E.
Photochemistry in medicine. Techniques for the analysis of photodegradation pathways of medicinal compounds.
Trends Anal. Chem., 6, 234-238, 1987. - BJ Wilkins, and DE Moore,
Photolytic rearrangement of metronidazole to 1-hydroxyethyl4-hydroxyimino5-oxo-imidazole and the formation of copper complexes of these compounds.
Photochem. Photobiol., 1988, 47, 481-484. - SR Tamat, DE Moore, A Patwardhan, and P Hersey,
Boronated monoclonal antibody 225.28S for potential use in neutron capture therapy of malignant melanoma.
Pigment Cell Res., 2, 278-280, 1989. - S Corderoy-Buck, BJ Allen, JG Wilson, JK Brown, M Mountford, W Tjarks,
D Gabel, D Barkla, A Patwardhan, AK Chandler and DE Moore,
Investigation of boron conjugated thiouracil derivatives for neutron capture
therapy of melanoma,
Advances in Radiopharmacol., Edited by DJ Maddalena, GM Snowdon, GR Boniface, 1989, pp 114-127. - DE Moore, and BJ Wilkins,
Common products from g-radiolysis and UV photolysis of metronidazole,
Radiat. Phys. Chem., 36, 547-550, 1990. - JV Fraser, CC Duke, GM Holder and DE Moore,
The solvolysis of the bay-region diolepoxides of 7-methylbenz[c]-acridine in aqueous solution and the effect of DNA.
Chem. Res. Toxicol., 3, 125-132, 1990. - DE Moore, S Roberts-Thomson, Z Dong and CC Duke,
Photochemical studies on the anti-inflammatory drug diclofenac.
Photochem. Photobiol., 52, 685-690, 1990. - DE Moore,
Photochemistry of photosensitizing drugs.
Trends Photochem. Photobiol., 1, 13-23, 1990. - HH Tonnesen and DE Moore,
Photochemical stability of biologically active compounds. III. Mefloquine as a photosensitizer.
Int. J. Pharm., 70, 95-101, 1991. - J Wang and DE Moore,
A study of the photodegradation of benzydamine in pharmaceutical formulations.
J. Pharm. Biomed. Anal., 7, 535-540 (1992). - JK Prashar, DE Moore, JG Wilson and BJ Allen,
Synthesis of carboranyl phenyl-alanine for potential use in neutron capture therapy. In: Advances in Neutron Capture Therapy, (edited by AH Soloway, RF Barth and DE Carpenter)
Plenum Press, 1993, pp 265-268. - JK Prashar and DE Moore,
Synthesis of carboranyl phenylalanine for potential use in neutron capture therapy of melanoma.
J. Chem. Soc. Perkin Trans. 1, 1993, 1051-1053. - JK Prashar, D Lama and DE Moore,
Synthesis of dihydroxycarboranyl phenylalanine for potential use in neutron capture therapy of melanoma.
Tetrahedron Lett. 34, 6799-6800, 1993. - W Zhou and DE Moore,
Photochemical decomposition of sulfamethoxazole.
Int. J. Pharm., 110, 55-63, 1994. - MD Smith, Y Setiawan and DE Moore,
Optimization of drug anchor for ortho-carborane in reconstitution of low density lipoproteins for neutron capture therapy. In: Cancer Neutron Capture Therapy, (edited by Y Mishima) Plenum Press, New York, 1996, pp 143-149. - C Suarna, RT Dean, PT Southwell-Keeley, DE Moore and R Stocker,
Separation and characterization of cholesteryl oxo- and hydroxy-linoleate isolated from human atherosclerotic plaque.
Free Radical Res., 27, 397-408, 1997. - DE Moore and J Wang,
Electron transfer mechanisms in photosensitization by the anti-inflammatory drug benzydamine.
J Photochem Photobiol., 43, 175-180, 1998. - DE Moore, Mechanisms of photosensitization by phototoxic drugs.
Mutation Research, 442, 165-173, 1998. - DE Moore, Photochemistry of diuretic drugs in solution.
In: Drugs - Photochemistry and Photostability, edited by A Albini and E Fasani,
Royal Society of Chemistry, 1998, pp 100-115. - DE Moore, K A Ghebremeskel, B B C Chen and E Y L Wong,
Electron transfer processes in the reactivity of nonsteroidal anti-inflammatory drugs in the ground and excited states. Photochem Photobiol, 68, 685-691, 1998. - YNB Li, DE Moore and BN Tattam,
Photodegradation of amiloride in aqueous solution.
Int J Pharm, 183, 109-116, 1999. - AG Kazemifard, DE Moore and A Aghazadeh, Identification and quantitation of sodium thyroxine and its degradation products by LC using electrochemical and MS detection. J. Pharm. Biomed. Anal, 25, 697-711, 2001.
Assoc Prof Gerald M Holder
- A. Bobik, G.M. Holder, and A.J. Ryan,
J. Med. Chem., 20, 1194-9 (1977).
Inhibitors of mixed function oxidase. The inhibition of hepatic microsomal aniline hydroxylase and aminopyrine demethylase by 2,6-, and 2,4-dihydroxyphenyl alkyl ketones and related compounds. - S. Chaturapit, and G.M. Holder, Biochem. Pharmac., 27, 1865-71 (1978).
Studies on the hepatic microsomal metabolism of [14C]-phenanthrene. - J.S.E. Holker, W.R. Jones, M.G.R. Leeming, G.M. Holder, J.M. Midgley, J.E. Parkin, and W.B. Whalley, J. Chem. Soc. Perkin I, 253-60 (1978). Conformational studies. Part 9. Some exceptions to the axial halogeno-ketone rule.
- G.M. Holder, J.L. Plummer, and A.J. Ryan,
Xenobiotica, 8, 761-8 (1978). The metabolism and excretion of curcumin (1,7-bis-(4-hydroxy-3-methoxy) 1,6 heptadien-3,5-dione) in the rat. - H.T.A. Cheung, G.M. Holder, and L. Moldovan,
J. Labelled Cpd. Radiopharm., 17, 121-8 (1980).
14C-and 3H-labelled 7-methylbenz[c]acridine. - R.S.U. Baker, A.M. Bonin, G.M. Holder, and I. Stupans,
Mutat. Res., 71, 43-52 (1980)
Comparison of the rat and guinea pig as sources of the S-9 fraction in the Salmonella/mammalian microsome mutagenicity test. - D.J. Wright, and G.M. Holder, Xenobiotica, 10, 265-70 (1980).
The metabolism of some food additives related to piperonal in the rabbit. - L.J. Boux, H.T.A. Cheung, G.M. Holder, and L. Moldovan,
Tetrahedron Lett., 21, 2923-6 (1980). Potential metabolites of carcinogenic aza-aromatic hydrocarbons: synthesis of K-region oxide, phenol, and dihydrodiols of 7-methylbenz[c]acridine. - G.M. Holder, C.M. Ireland, and A.J. Ryan,
Biochem. Pharmac., 30, 2685-90 (1981).
Studies on the metabolism of carcinogenic polycyclic heteroaromatic compounds. The hepatic microsomal metabolism of 7-methylbenz[c]acridine. - G.M. Holder, B. Tierney, and E. Bresnick,
Cancer Res., 41, 4408-14 (1981). Benzo[a]pyrene binding to cytosolic protein, its nuclear uptake and subsequent metabolism. - L.J. Boux, C.M. Ireland, D.J. Wright, G.M. Holder, and A.J. Ryan, J. Chromatogr., 227, 149-57 (1982). TLC and HPLC separation of the metabolites of the weak carcinogen, 7-methylbenz[c]acridine.
- C.M. Ireland, H.T.A. Cheung, G.M. Holder, and A.J. Ryan,
Chem. Biol. Interact., 40, 305-18 (1982).
Rat liver microsomal metabolites of 7-methylbenz[c]acridine. - B.V. Lap, L.J. Boux, H.T.A. Cheung, and G.M. Holder,
J. Heterocycl. Chem., 20, 281-4 (1983).
Synthetic studies on potential metabolites of carcinogenic aza-aromatic hydrocarbons. Non-K-region oxidised and reduced derivatives of 7-methylbenz[c]acridine. - L.J. Boux, C.C. Duke, G.M. Holder, C.M. Ireland, and A.J. Ryan,
Carcinogenesis, 4, 1429-35 (1983). Metabolism of 7-methylbenz[c]acridine: comparison of rat liver and lung microsomal preparations and the identification of some minor metabolites. - C.C. Duke, P.M. Murphy, and G.M. Holder,
J. Org. Chem., 49, 4446-51 (1984).
Synthesis of the non-K-region dihydrodiols of the carcinogen, 7-methylbenz[c]acridine. - L.J. Boux, and G.M. Holder,
Xenobiotica, 15, 11-20 (1985) The metabolism of the carcinogen, 7-methylbenz[c]acridine, by hepatocytes isolated from untreated and induced rats. - L.J. Boux, and G.M. Holder,
Cancer Lett., 25, 333-342 (1985).
Studies on the in vivo and in vitro binding of the carcinogen, 7-methylbenz[c]acridine, to DNA. - D.J. Wright, H. Robinson, G.M. Holder, A.J.Ryan, A.M. Bonin and R.S.U. Baker,
Xenobiotica, 15, 825-834 (1985).
The metabolism of the carcinogen, 7-methylbenz[c]acridine, in the rat. - A.M. Bonin, I. Stupans, R.S.U. Baker, A.J. Ryan and G.M. Holder,
Mutat. Res., 158, 111-117 (1985). The effect of induction by DDT on the metabolism and mutagenicity of benzo[a]pyrene. - R.L. Chang, W. Levin, A.W. Wood, N. Shirai, A.J. Ryan, C.C. Duke, D.M. Jerina, G.M. Holder and A.H. Conney, Cancer Res., 46, 4552-4555 (1986). High tumorigenicity of the 3,4-dihydrodiol of 7-methylbenz[c]acridine on mouse skin and in the newborn mouse.
- J.H. Gill, A.M. Bonin, E. Podobna, R.S.U. Baker, C.C. Duke, C.A. Rosario, A.J Ryan and G.M. Holder, Carcinogenesis, 7, 23-31 (1986). 7-Methylbenz[c]acridine: mutagenicity of some of its metabolites and derivatives, and the identification of trans-3,4-dihydro-3,4-dihydroxy-7-methylbenz[c]acridine as a microsomal metabolite.
- J.H. Gill, and G.M. Holder,
J. Pharmaceut. Biomed. Anal., 4, 31-36 (1986). The application of synchronous luminescence to the determination of cochromatographing metabolites of the carcinogen, 7-methylbenz[c]acridine. - C.D. Burt, H.T.A. Cheung, G.M. Holder and D.E. Moore,
J. Chem. Soc. Perkin I, 741-745 (1986). Photooxidation of 7-methylbenz[c]acridine in methanol: identification of two primary photoproducts. - J.H. Gill, C.C. Duke, C.A. Rosario, G.M. Holder and A.J. Ryan,
Carcinogenesis, 7, 1371-1378 (1986). Dibenz[a,j]acridine metabolism: identification of metabolites formed in vitro by liver microsomes from 3-methylcholanthrene induced rats - C.A. Rosario, C.C. Duke, J.H. Gill, M. Dawson, G.M. Holder, T. Ghazy, M.A. Long, J. Labelled Cmpd Radiopharm., 24, 23-28 (1987). The preparation of regiospecific tritiated and deuterated dibenzacridines by catalytic exchange and of 14C-dibenz[a,j]acridine.
- J.H. Gill, C.C. Duke, A.J. Ryan and G.M. Holder,
Carcinogenesis, 8, 425-431 (1987). Dibenz[a,j]acridine: distribution of metabolites formed by lung and liver microsomes from control and pretreated animals. - C.A. Rosario, C.C. Duke and G.M. Holder,
J. Org. Chem., 52, 1064-1072 (1987).
Synthesis of potential metabolites of dibenz[a,j]acridine: dihydrodiols and phenols. - C.C. Duke and G.M. Holder,
J. Chromatogr., 430, 53-64 (1988)
endo-1,4,5,6,7,7-Hexachlorobicyclo[2.2.1]hept-5-en-2-carboxylic acid, a superior resolving agent for the HPLC separation of enantiomers of hydroxylated derivatives of two aza-aromatic hydrocarbons. - C.C. Duke, G.M. Holder, C.A. Rosario and A.J. Ryan,
Chemical Research Toxicol., 1, 294-303 (1988).
Stereochemistry of the major rodent liver microsomal metabolites of the carcinogen dibenz[a,j]acridine. - A.M. Bonin, C.A. Rosario, C.C. Duke, R.S.U. Baker, A.J. Ryan and G.M. Holder, Carcinogenesis, 10, 1079-1084 (1989). The mutagenicity of dibenz[a,j]acridine, some metabolites and other derivatives in bacteria and mammalian cells.
- J.M. Sayer, R.E. Lehr, S. Kumar, H. Yagi, H.J.C. Yeh, G.M. Holder, C.C. Duke J.V. Silverton
C. Gibson and D.M. Jerina,
J. Amer. Chem. Soc., 112, 1177-1185 (1990).
Comparative solvolytic reactivity of bay-region diolepoxides derived from dibenz[a,j]
anthracene and dibenzacridines. - H.K. Robinson, C.C. Duke, G.M. Holder and A.J. Ryan,
Xenobiotica, 20, 457-470 (1990).
The metabolism of the carcinogen dibenz[a,j]acridine in isolated rat hepatocytes and in vivo in rats - J.V. Fraser, C.C. Duke, G.M. Holder and D.E. Moore,
Chemical Research Toxicol., 3, 125-132 (1990).
Solvolysis of the bay-region diol epoxides of 7-methylbenz[c]acridine in aqueous solution and effect of DNA. - Sugiyanto, G.M. Holder and A.J. Ryan,
J. Chromatogr., 530, 337-346 (1990) High performance liquid chromatographic method for the determination of polycyclic hydrocarbon metabolite distributions. - C.C. Duke, T.W. Hambley, G.M. Holder, C.O. Navascues, S. Roberts-Thomson, and Y. Ye,
Chemical Research Toxicol., 4, 546-555 (1991) The stereochemistry of the major rat liver metabolites of the carcinogen, 7-methylbenz[c]acridine. - S.R. Carter, C.C. Duke, D.J. Cutler, and G.M. Holder,
J. Chromatogr., 574, 77-83 (1992)
A sensitive stereospecific assay of warfarin in plasma: reversed phase high performance liquid chromatographic separation using diastereoisomeric esters(-)-(1S,2R,4R)-endo-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2-carboxylic acid. - C.E.Scharping, M.E.McManus and G.M.Holder,
Carcinogenesis, 13, 1199-1207 (1992)
NADPH-Supported and arachidonic acid-supported metabolism of the enantiomer 7,8-dihydrobenzo[a]pyrene-7,8-dihydrodiol by human liver microsomal samples. - Sugiyanto, C.E. Scharping, M.E. McManus, D.J. Birkett, G.M. Holder, and A.J. Ryan,
Xenobiotica, 11, 1299-1307 (1992)
The formation of proximate carcinogens from three polycyclic aromatic compounds by human liver microsomes. - C.E. Scharping, C.C. Duke, G.M. Holder and D. Larden,
Carcinogenesis, 14, 1041-1047 (1993)
The hepatic metabolism of two methylquinolines. - Y. Ye, G.M. Holder and C.C. Duke,
J. Labelled Cmpds Radiopharm., 33, 1-10 (1993)
The preparation of 2H and 3H-labelled 7,9-and 7,10-dimethylbenz-[c]acridine by catalytic dehalogenation. - S. Roberts-Thomson, M.E. McManus, R.H. Tukey, F.F. Gonzalez and G.M. Holder,
Biochem. Biophys. Res. Comm., 192, 1373-1379 (1993)
The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen. - C.C. Duke, S. Carter, T. Hambley, G.M. Holder and D. Cutler, Chirality, 6, 670-680 (1994) Analysis of warfarin enantiomers: chromatographic separation of six stereoisomeric esters prepared from (-)-(1S,2R,4R)-endo-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2-carboxylic acid.
- Yuerong Ye, C.C. Duke and G.M. Holder,
Chem. Res. Toxicol., 8, 188-199 (1995)
Identification of hepatic metabolites of two highly carcinogenic polycyclic aza-aromatic compounds, 7,9-dimethylbenz[c]acridine and 7,10-dimethylbenz[c]acridine. - Yuerong Ye, C.C. Duke and G.M. Holder,
Chem. Res. Toxicol., 8, 200-208 (1995)
The stereochemistry of the major rat hepatic microsomal metabolites of 7,9-dimethylbenz[c]acridine and 7,10-dimethylbenz[c]acridine. - Yuerong Ye, C.E. Scharping and G.M. Holder, Carcinogenesis, 16, 787-793 (1995)
The hepatic metabolism of two carcinogenic dimethylbenzacridines in control and induced rats: the distribution and mutagenicity of metabolites. - S. Roberts-Thomson, M.E. McManus, R.H. Tukey, F.J. Gonzalez and G.M. Holder,
Cancer Res., 55, 1052-1059 (1995)
Polycyclic aza-aromatic carcinogens metabolism catalysed by four expressed human cytochromes P450. - S. Roberts-Thomson, M.E. McManus, Colin C. Duke, R. Agnew and G.M. Holder,
Mol. Pharmacol., 49, 105-111 (1996). Stereoselective and regioselective hydration of 7-methylbenz[c]acridine by rodent and human microsomal epoxide hydrolase. - G.M. Holder,
Chem. Aust., 63, 224-225 (1996)
Stereochemistry in drug metabolism and toxicity. - A.N. Oglobline, G.E. O'Donnell, R. Geyer, G.M. Holder and B. Tattam,
J Anal. Toxicol., 25, 153-157. Routine gas chromatographic determination of dialkylphosphate metabolites in the urine of workers occupationally exposed to OP insecticides. - A.N. Oglobline, H. Elimelekh, B. Tattam, R. Geyer, G.E. O'Donnell and G. Holder,
Analyst, 126,
Negative ion chemical ionization GC/MS-MS analysis of dialkylphosphate metabolites of OP pesticides in urine of non-occupationally exposed
Dr John H Vine
- "Metabolism and urinary excretion of chlormethiazole in humans", R.G. Moore, A.V. Robertson, M.P. Smyth, J. Thomas and J. Vine, Xenobiotica, 5, 687 (1975).
- "Metabolism of etidocaine in man",
J. Thomas, D. Morgan and J. Vine,
Xenobiotica, 6, 39 (1976). - "Cyclic metabolites of etidocaine in humans",
D.J. Morgan, M.P. Smyth, J. Thomas and J. Vine,
Xenobiotica, 7, 365 (1977) - "Plasma levels of chlormethiazole and two metabolites after oral administration to young and aged human subjects",
R.L. Nation, J.Vine, E.J.Triggs and B. Learoyd,
European Journal of Clinical Pharmacology, 12, 137 (1977). - "Metabolism and urinary excretion of benzhexol in humans",
J. Vine, R.L. Nation and E.J. Triggs,
Xenobiotica, 8, 165 (1978). - "The identification of eight hydroxylated metabolites of etidocaine by chemical ionisation mass spectrometry",
J.Vine, D.Morgan and J. Thomas,
Xenobiotica, 8, 509 (1978). - "Cardenolide analogues 10 - Characterisation of cardiac glycosides by
chemical ionization mass spectrometry",
J.Vine, L. Brown, J. Boutagy, R. Thomas and D. Nelson,
Biomedical Mass Spectrometry, 6, 415 (1979). - "Quantitation of doxapram in blood, plasma and urine",
H.Nichol, J.Vine, J.Thomas and R.G.Moore,
Journal of Chromatography, 182, 191, (1980). - "Quantitation of ibuprofen in biological fluids by gas chromatography-mass spectrometry",
J.Whitlam and J. Vine,
Journal of Chromatography, 181, 463 (1980). - "Analysis of fatty acid methyl esters by high resolution gas chromatography-chemical ionisation mass spectrometry",
J.Vine, Journal of Chromatography, 196, 415 (1980). - "Characterisation of two ornithine-containing lipids from Erwina Aroideae",
V.N. Madhavan, J. Done and J. Vine, Chemistry and Physics of Lipids, 28, 79 (1981). - "Leaching of a contaminant into the contents of disposable syringes", M.C.Peterson, J.Vine, J.J.Ashley and R.L.Nation,
Australian and New Zealand Journal of Medicine, 11, 208 (1981). - "Leaching of 2-(2-hydroxyethylmercapto)benzothiazole into the contents of disposable syringes",
M.C.Petersen, J.Vine, J.J. Ashley and R.L. Nation,
Journal of Pharmaceutical Science, 70, 1139, (1981). - "2H-labelled 3 -hydroxy-5 -pregnane-11,20-dione and 3,21 -dihydroxy-5 -pregnane-11,20-dione 21-acetate", J.Vine and K.Treloar,
Journal of Labelled Compounds and Radiopharmaceuticals, 9, 597 (1982). - "Dormancy in somatic embryos and seeds of Vitis: Changes in endogenous abscisic
acid during embryogeny and germination",
K.Rajasekaran, M.G.Mullins and J. Vine,
Planta, 154, 139 (1982). - "Incidence of drug and alcohol intake in road traffic accident victims",
J. Vine and T.R. Watson, Medical Journal of Australia, 1, 1612 (1983). - "A rapid extraction method for acid drugs in hemolyzed blood",
B. Ford, J. Vine and T.R. Watson,
Journal of Analytical Toxicology, 7, 116 (1983). - "Three new contaminants detected in post mortem blood samples",
J. Vine, T.R. Watson and B. Ford, Journal of Analytical Toxicology, 8, 290 (1984). - "Determination of fatty acids of the bacteria streptomyces R61 and actinomadura
R39 by capillary gas chromatography-mass spectrometry",
A.S. Brown, H.T.A. Cheung, K.T. Cho, V.Hemmens and J. Vine,
Journal of Chromatography, 341, 139 (1985). - "Synthesis of 2H8-leukotriene B4",
M.Dawson, J.H.Vine, M.J.Forrest, C.M.McGee, P.M.Brooks and T.R.Watson,
Journal of Labelled Compounds and Radiopharmaceuticals, 24, 291 (1987). - "Rapid and sensitive detection of drugs in blood by gas chromatography/mass spectrometry/mass spectrometry",
J.H.Vine, T.R. Watson, M.A. Dodson and G.A.Starmer,
Alcohol, Drugs and Traffic Safety, Excerpta Medica, International Congress Series, 721, 407 (1987). - "Quantitation of biphenylacetic acid in plasma and synovial fluid by gas
chromatography/mass spectrometry/mass spectrometry",
M.Dawson, C.M.McGee, P.M.Brooks, J.H.Vine, E.Lacey and T.R.Watson,
Journal of Chromatography, 420, 129 (1987). - "The identification and analysis of the C7 and C9 fraction from petroleum
distillation using a capillary gas chromatograph-mass spectrometry data system",
B.P.Cairns, D.M.Nobbs, I.A.Furzer and J.H.Vine,
Proceedings of the Ninth Australian Symposium on Analytical Chemistry, Sydney, 257 (1987). - "A comparison of gas chromatography/tandem mass spectrometry and hplc for
low level drug quantitative analysis", C.M.McGee, M.Dawson, J.H. Vine and P.M.Brooks. Proceedings of the Ninth Australian Symposium on Analytical Chemistry, Sydney, 313 (1987). - "Analysis of eicosanoids by gas chromatography/tandem mass spectrometry,
M.Dawson, J.H.Vine, C.M.McGee, P.M. Brooks and T.R.Watson.
Proceedings of the Ninth Australian Symposium on Analytical Chemistry, Sydney, 317 (1987). - "Simultaneous quantitation of indole-3-acetic acid and abscisic acid in small samples of plant tissue by gas chromatography/mass spectrometry",
J.H.Vine, D.Noiton, J.A.Plummer, C.Baleriola-Lucas and M.G.Mullins, Plant Physiology, 85, 419 (1987). - "The disposition of biphenylacetic acid following topical application",
M.Dawson, C.M.McGee, J.H.Vine, P.Nash, T.R.Watson and P.M. Brooks,
European Journal of Clinical Pharmacology, 33, 639 (1988). - "A Co-ordinated approach to the drugs and traffic safety problem",
G.A.Starmer, J.H.Vine and T.R.Watson,
Medicines and Road Traffic Safety, Eds. D.Burley and T. Silverston,
Clinical Neuroscience Publishers (London) 35-53 (1988). - "Quantitation of leukotriene B4 in synovial fluid by gas chromatography/mass spectrometry/mass spectrometry",
M.Dawson, J.H.Vine, C.M.McGee, P.M.Brooks and T.R.Watson,
Biomedical and Environmental Mass Spectrometry, 17, 205 (1988). - "Synthesis of deuterium labelled non-steroidal anti-inflammatory drugs",
M.Dawson, C.M.McGee and J.H.Vine, Journal of Labelled Compounds and Radiopharmaceuticals, 27, 707 (1989). - "Lipid profile of Pleurotus Sajor Caju",
N.G.Nair, C.H.Song, J.Y.Jiang, J.H.Vine, B.Tattam and K.Y.Cho,
Ann. Appl. Biol. 114, 167 (1989). - "Rapid and sensitive detection of drugs in blood by gas chromatography/mass spectrometry/mass spectrometry",
J.H.Vine, T.R.Watson, M.A.Dodson and G.A.Starmer,
Screening for Drug Abuse - A Community Challenge, The Clinical Biochemist, 41 (1991). - "Seasonal changes in endogenous ABA and IAA and the influence of applied ABA and auxin in relation to shoot growth and abscission in valencia orange (Citrus sinensis (L.) Osbeck),
J.A.Plummer, M.G.Mullins and J.H.Vine,
Plant Growth Regulators, 10, 139 (1991). - "Regulation of stem abscission and callus growth in shoot explants of sweet orange
(Citrus sinensis (L.) Osbeck),
J.A.Plummer, J.H.Vine, and M.G.Mullins,
Ann. Bot. (Lond) 67, 17 (1991). - "Endogenous indole-3-acetic acid and abscisic acid in apple microcuttings in relation to adventitious root formation",
D.Noiton, J.H.Vine and M.G.Mullins,
Plant Growth Regulators, 11, 63 (1992). - "Effects of psychoactive drugs on car driving performance: drugs in crash-involved drivers", G.A. Starmer, D. Cairns, D.J. Mascord, J. Perl, B. Tattam, J.H. Vine and T.R. Watson, Clin. Neuropharm. 15, supp 1, 598A-600A (1992).
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