Pharmaceutics

Research in Pharmaceutics focuses on:-

• formulation, drug delivery including formulation/delivery of protein and biotechnology drugs.
• membrane transport and interaction of drugs with macromolecules.
• preclinical (animal) and clinical (patient) pharmacokinetics and pharmacodynamics.

• Formulation and delivery of proteins and drugs
• Pharmacokinetics and Pharmacodynamics
• Pharmaceutics Research 2002

• Stabilisation of therapeutic proteins in the dry state for drug delivery
• Formulation of microparticles of drugs, peptides and proteins for potential nasal, pulmonary or oral delivery
• The preparation and in vitro characterisation of pharmaceutical aerosols of drugs and proteins
• Study of the in vivo deposition of aerosols using gamma scintigraphy techniques
• Study of the systemic absorption of drugs given by inhalation
• Formulation and manufacture of low solubility drugs for oral delivery

• Investigation of pharmacokinetics and pharmacodynamics of drugs under different physiological conditions such as obesity and pregnancy and various disease states like diabetes
• Pharmacodynamics of neuromuscular blocking drugs in adults and children
• Use of neuromuscular paralysis as a pharmacodynamic probe of liver function during liver transplantation surgery
• Drug disposition and metabolism in the isolated perfused rat liver preparation
• Population pharmacokinetic investigations in special subgroups of patients including children with malignant disease, transplant recipients, people with HIV infection and patients with rheumatoid arthritis
• In vitro metabolism of inhaled glucocorticoids in homogenates of human lung, liver and gut tissue
• The distribution and disposition of immunosuppressants and other drugs in transplant recipients any corrections or amendments that may be required) and printed on acid-free or permanent paper
• Development of theoretical pharmacokinetic models to describe drug absorption, distribution and elimination processes
• Using physiologically-based pharmacokinetic models to describe and predict drug disposition
• Examination of pharmacodynamic drug interactions with neuromuscular blocking and other drugs used during anaesthesia using in vivo models
  Renal handling of drugs
• Application of artificial neural networks in pharmacokinetics
• Pharmacokinetic/pharmacodynamic investigation of highly extracted drugs in experimental colitis, arthritis and endotoxemia
• Pharmacokinetic/pharmacodynamic investigation of chiral proton pump blockers
• Microdialysis as a research tool in pharmacokinetics and pharmacodynamics
• Studies on pharmaceutical powders
• Characterisation of the solid state properties of pharmaceutical powders including mixing and flow properties
• Identification of physical forms of drugs such as polymorphs, solvates and crystal habits